A quantitative theory of the functions of the hippocampal CA3 network in memory.
A quantitative theory of the functions of the hippocampal CA3 network in memory.
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DOI：
10.3389/fncel.2013.00098
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发表时间：
2013
影响因子：
5.3
通讯作者：
Rolls ET
中科院分区：
文献类型：
--
作者：
Rolls ET
描述了海马CA3系统作为情景记忆系统中使用的自关联或吸引子网络的操作的定量计算理论。在这一理论中，CA3系统作为一个单一的吸引子或自动关联网络运行，使任何空间位置（啮齿动物的位置或灵长类动物的空间视图）与物体或奖励之间的快速、一次试验的关联成为可能，并在回忆任何部分时提供完整的记忆。这一理论被扩展到时间与物体或奖励之间的联系，以实现时间顺序记忆，这在情景记忆中也很重要。齿状回（DG）通过竞争性学习进行模式分离，以产生适合于在学习过程中在CA3中建立新表征的稀疏表征，例如，从内嗅皮层网格细胞产生具有位置样场的神经元。齿状颗粒细胞通过极少量的苔藓纤维（MF）连接到CA3产生一种随机模式分离效应，这种效应在学习过程中很重要，但在回忆过程中并不重要，它将CA3激活所代表的模式分离出来，使其彼此非常不同，这对于非结构化情景记忆系统来说是最佳的，因为每个记忆都必须与其他记忆区分开来。直接射孔路径（pp）输入CA3在数量上适合为CA3中的回忆提供线索，但不适合学习。该理论的测试包括海马体亚区分析和海马体NMDA受体敲除描述，并支持该理论。
A quantitative computational theory of the operation of the hippocampal CA3 system as an autoassociation or attractor network used in episodic memory system is described. In this theory, the CA3 system operates as a single attractor or autoassociation network to enable rapid, one-trial, associations between any spatial location (place in rodents, or spatial view in primates) and an object or reward, and to provide for completion of the whole memory during recall from any part. The theory is extended to associations between time and object or reward to implement temporal order memory, also important in episodic memory. The dentate gyrus (DG) performs pattern separation by competitive learning to produce sparse representations suitable for setting up new representations in CA3 during learning, producing for example neurons with place-like fields from entorhinal cortex grid cells. The dentate granule cells produce by the very small number of mossy fiber (MF) connections to CA3 a randomizing pattern separation effect important during learning but not recall that separates out the patterns represented by CA3 firing to be very different from each other, which is optimal for an unstructured episodic memory system in which each memory must be kept distinct from other memories. The direct perforant path (pp) input to CA3 is quantitatively appropriate to provide the cue for recall in CA3, but not for learning. Tests of the theory including hippocampal subregion analyses and hippocampal NMDA receptor knockouts are described, and support the theory.
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