Morphology of Photopolymerized End-linked Poly(ethylene glycol) Hydrogels by Small Angle X-ray Scattering.
Morphology of Photopolymerized End-linked Poly(ethylene glycol) Hydrogels by Small Angle X-ray Scattering.
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DOI：
10.1021/ma101070s
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发表时间：
2010-08-24
期刊：
影响因子：
5.5
通讯作者：
Frank CW
中科院分区：
文献类型：
--
作者：
Waters DJ;Engberg K;Parke-Houben R;Hartmann L;Ta CN;Toney MF;Frank CW
由于聚（乙二醇）（PEG）的生物相容性，基于PEG的水凝胶作为生物材料在组织工程应用中引起了相当大的兴趣。在这项工作中，我们表明，通过光聚合的PEG大分子单体与丙烯酸酯或丙烯酰胺端基官能化制备的基于PEG的水凝胶生成网络与高功能的交联点。尽管交联官能度没有得到很好的控制，但所得网络足够有序，以在与PEG网络内交联点之间的距离相关的小角X射线散射（SAXS）中产生明显的相关峰。交联间距是水凝胶内PEG链构象的有用探针，范围为约6至16 nm，取决于聚合物的体积分数和PEG大分子单体的分子量。光聚合的PEG网络的散射峰的存在也与增强的压缩模量相关联，与文献中报道的具有低得多的交联官能度的PEG网络相比，其没有表现出散射峰。该比较表明，用于将PEG大分子单体连接在一起的方法对所得水凝胶网络的纳米级结构和宏观性质都具有关键影响。
Due to the biocompatibility of poly(ethylene glycol) (PEG), PEG-based hydrogels have attracted considerable interest for use as biomaterials in tissue engineering applications. In this work, we show that PEG-based hydrogels prepared by photopolymerization of PEG macromonomers functionalized with either acrylate or acrylamide end-groups generate networks with crosslink junctions of high functionality. Although the crosslink functionality is not well controlled, the resultant networks are sufficiently well ordered to generate a distinct correlation peak in the small angle x-ray scattering (SAXS) related to the distance between crosslink junctions within the PEG network. The crosslink spacing is a useful probe of the PEG chain conformation within the hydrogel and ranges from approximately 6 to 16 nm, dependent upon both the volume fraction of polymer and the molecular weight of the PEG macromonomers. The presence of a peak in the scattering of photopolymerized PEG networks is also correlated with an enhanced compressive modulus in comparison to PEG networks reported in the literature with much lower crosslink functionality that exhibit no scattering peak. This comparison demonstrates that the method used to link together PEG macromonomers has a critical impact on both the nanoscale structure and the macroscopic properties of the resultant hydrogel network.
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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