Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel.
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel.
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DOI：
10.1126/science.abl4292
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发表时间：
2022-03-11
期刊：
影响因子：
56.9
通讯作者：
Pitzer, Virginia E.
中科院分区：
文献类型：
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作者：
Prunas, Ottavia;Warren, Joshua L.;Crawford, Forrest W.;Gazit, Sivan;Patalon, Tal;Weinberger, Daniel M.;Pitzer, Virginia E.
针对 COVID-19 的疫苗在个体层面的有效性已得到充分证实。然而，很少有研究检验疫苗对传播的有效性。我们使用链二项式模型来评估在 Delta 变种出现之前和之后，在以色列接种 BNT162b2（基于辉瑞 BioNTech mRNA 的疫苗）预防 SARS-CoV-2 家庭传播的有效性。疫苗接种使感染易感性降低了 89.4% [95% 置信区间 (CI)：88.7%, 90.0%]，而在 2021 年 6 月 1 日之前第二次接种后第 10 至 90 天，疫苗针对感染后传染性的有效性为 23.0% (95% CI: -11.3%, 46.7%)。疫苗总有效性为 91.8% (95%) 置信区间：88.1%、94.3%）。然而，由于免疫力减弱和 Delta 变种出现的综合影响，疫苗的有效性随着时间的推移而降低。
The individual-level effectiveness of vaccines against COVID-19 is well established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 (Pfizer-BioNTech mRNA-based vaccine) against household transmission of SARS-CoV-2 in Israel before and after the Delta variant emerged. Vaccination reduced susceptibility to infection by 89.4% [95% confidence interval (CI): 88.7%, 90.0%], whereas vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: −11.3%, 46.7%) during days 10 to 90 after the second dose before June 1, 2021. Total vaccine effectiveness was 91.8% (95% CI: 88.1%, 94.3%). However, vaccine effectiveness is reduced over time as a result of the combined effect of waning of immunity and the emergence of the Delta variant.
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影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
DOI：
10.1016/j.cmi.2021.01.011
发表时间：
2021-04
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Qiu X;Nergiz AI;Maraolo AE;Bogoch II;Low N;Cevik M
通讯作者：
Cevik M
影响因子：
4.2
作者：
Richterman A;Block JP;Tsai AC;Ivers LC
通讯作者：
Ivers LC
影响因子：
1.9
作者：
RAMPEY, AH;LONGINI, IM;MONTO, AS
通讯作者：
MONTO, AS
DOI：
10.1016/s1473-3099(20)30985-3
发表时间：
2021-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Marks M;Millat-Martinez P;Ouchi D;Roberts CH;Alemany A;Corbacho-Monné M;Ubals M;Tobias A;Tebé C;Ballana E;Bassat Q;Baro B;Vall-Mayans M;G-Beiras C;Prat N;Ara J;Clotet B;Mitjà O
通讯作者：
Mitjà O