The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission-a living systematic review.
The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission-a living systematic review.
复制标题
DOI：
10.1016/j.cmi.2021.01.011
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Cevik M
中科院分区：
文献类型：
--
作者：
Qiu X;Nergiz AI;Maraolo AE;Bogoch II;Low N;Cevik M
报告表明，无症状个体（在整个感染过程中没有任何症状）感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）具有传染性，但基于症状状态的传播程度需要进一步研究。这篇活的评论旨在批判性地评估关于无症状、症状前和症状性SARS-CoV-2感染者继发性发作率的现有数据。使用相关MESH术语检索了Medline、EMBASE、中国学术期刊全文数据库（CNKI）和预印本服务器（2019年12月30日至2020年7月3日）。纳入了以英文或中文报告SARS-CoV-2感染指示病例接触者追踪的研究。两位作者独立提取数据并评估研究质量和偏倚风险。我们计算了二次发病率，即与SARS-CoV-2接触的人数除以测试的接触人数。在确定的927项研究中，纳入了80项。总结二次发作率估计为1%（95% CI 0%-2%），10项研究中无症状索引病例的预测区间为0%-10%，占7%（95% CI 3%-11%），11项研究中症状前病例的预测区间为1%-40%，6%（95% CI 5%-8%），40项研究中有症状指数病例的预测区间为5%-38%。在与指示病例生活在同一家庭的接触者中发现了最高的二次发病率。与传播有关的其他活动是集体活动，如与指示病例一起吃饭或玩棋盘游戏，而不管指示病例的疾病状况如何。我们排除了一些研究，因为索引病例或接触人数不清楚。无症状的患者可以将SARS-CoV-2传播给其他人，但我们的研究结果表明，这些人比有症状的人更少引起继发感染。PROSPERO CRD 42020188168.
Reports suggest that asymptomatic individuals (those with no symptoms at all throughout infection) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are infectious, but the extent of transmission based on symptom status requires further study. This living review aims to critically appraise available data about secondary attack rates from people with asymptomatic, pre-symptomatic and symptomatic SARS-CoV-2 infection. Medline, EMBASE, China Academic Journals full-text database (CNKI), and pre-print servers were searched from 30 December 2019 to 3 July 2020 using relevant MESH terms. Studies that report on contact tracing of index cases with SARS-CoV-2 infection in either English or Chinese were included. Two authors independently extracted data and assessed study quality and risk of bias. We calculated the secondary attack rate as the number of contacts with SARS-CoV-2, divided by the number of contacts tested. Of 927 studies identified, 80 were included. Summary secondary attack rate estimates were 1% (95% CI 0%–2%) with a prediction interval of 0%–10% for asymptomatic index cases in ten studies, 7% (95% CI 3%–11%) with a prediction interval of 1%–40% for pre-symptomatic cases in 11 studies and 6% (95% CI 5%–8%) with a prediction interval of 5%–38% for symptomatic index cases in 40 studies. The highest secondary attack rates were found in contacts who lived in the same household as the index case. Other activities associated with transmission were group activities such as sharing meals or playing board games with the index case, regardless of the disease status of the index case. We excluded some studies because the index case or number of contacts were unclear. Asymptomatic patients can transmit SARS-CoV-2 to others, but our findings indicate that such individuals are responsible for fewer secondary infections than people with symptoms. PROSPERO CRD42020188168.
登录
查看更多内容
影响因子：
9.8
作者：
Althouse BM;Wenger EA;Miller JC;Scarpino SV;Allard A;Hébert-Dufresne L;Hu H
通讯作者：
Hu H
影响因子：
12
作者：
Hong, Lu-Xiao;Lin, Aifen;Yan, Wei-Hua
通讯作者：
Yan, Wei-Hua
影响因子：
82.9
作者：
Adam, Dillon C.;Wu, Peng;Cowling, Benjamin J.
通讯作者：
Cowling, Benjamin J.
影响因子：
11.8
作者：
Dawson, Patrick;Rabold, Elizabeth M.;Kirking, Hannah L.
通讯作者：
Kirking, Hannah L.
影响因子：
56.3
作者：
Boehmer, Merle M.;Buchholz, Udo;Zapf, Andreas
通讯作者：
Zapf, Andreas