Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea.
Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea.
复制标题
新诊断的阻塞性睡眠呼吸暂停男性患者固有低频振荡的频率特异性改变
DOI：
10.3389/fnins.2022.987015
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发表时间：
2022
影响因子：
4.3
通讯作者：
Peng, Dechang
中科院分区：
文献类型：
--
作者：
Zeng, Yaping;Shu, Yongqiang;Liu, Xiang;Li, Panmei;Kong, Linghong;Li, Kunyao;Xie, Wei;Zeng, Li;Long, Ting;Huang, Ling;Li, Haijun;Peng, Dechang
关键词：
先前的研究发现，阻塞性睡眠呼吸暂停（OSA）患者的异常低频自发性大脑活动与认知障碍有关。然而，目前尚不清楚低频自发性大脑活动是否与 OSA 患者的特定频段相关。本研究采用OSA患者低频波动幅度（ALFF）法探讨经典（0.01~0.1 Hz）和5个子频段（slow-2至slow-6）的自发脑活动特征，并分析自发脑活动与临床评价的关系。从 52 名新诊断的 OSA 患者和 62 名健康对照 (HC) 中收集了静息态磁共振成像数据和临床评估。我们计算了经典频段和五个不同子频段中的各个组 ALFF 值。双样本 t 检验比较了 ALFF 差异，单向方差分析探讨了两组之间频段的相互作用。 OSA组双侧楔前叶/后扣带回、双侧角回、左顶下小叶、脑干、右梭状回的ALFF值低于HC组。相比之下，OSA组双侧小脑后叶、双侧额上回、双侧额中回、左侧额下回、左侧颞下回、左侧梭状回的ALFF值高于HC组。改变大脑区域的一些 ALFF 值与体重指数、呼吸暂停低通气指数、颈围、打鼾史、最低 SaO2、平均 SaO2、觉醒指数、氧减少指数、深度睡眠周期命名、抽象和特定频段的延迟回忆相关。我们的结果表明 OSA 患者自发脑活动存在频率特异性差异，这与认知和其他临床症状有关。这项研究确定了与脑损伤相关的频段特征，扩展了认知神经影像机制，并提供了额外的 OSA 神经影像标记。
Previous studies found abnormal low-frequency spontaneous brain activity related to cognitive impairment in patients with obstructive sleep apnea (OSA). However, it is unclear if low-frequency spontaneous brain activity is related to specific frequency bands in OSA patients. In this study, we used the amplitude of low-frequency fluctuation (ALFF) method in patients with OSA to explore characteristics of spontaneous brain activity in the classical (0.01–0.1 Hz) and five sub-frequency bands (slow-2 to slow-6) and analyzed the relationship between spontaneous brain activity and clinical evaluation was analyzed. Resting-state magnetic resonance imaging data and clinical assessments were collected from 52 newly-diagnosed OSA patients and 62 healthy controls (HCs). We calculated the individual group ALFF values in the classical and five different sub-frequency bands. A two-sample t-test compared ALFF differences, and one-way analysis of variance explored interactions in frequency bands between the two groups. ALFF values in the OSA group were lower than those in the HC group in the bilateral precuneus/posterior cingulate cortex, bilateral angular gyrus, left inferior parietal lobule, brainstem, and right fusiform gyrus. In contrast, ALFF values in the OSA group were higher than those in the HC group in the bilateral cerebellum posterior lobe, bilateral superior frontal gyrus, bilateral middle frontal gyrus, left inferior frontal gyrus, left inferior temporal gyrus, and left fusiform gyrus. Some ALFF values in altered brain regions were associated with body mass index, apnea-hypopnea index, neck circumference, snoring history, minimum SaO2, average SaO2, arousal index, oxygen reduction index, deep sleep period naming, abstraction, and delayed recall in specific frequency bands. Our results indicated the existence of frequency-specific differences in spontaneous brain activity in OSA patients, which were related to cognitive and other clinical symptoms. This study identified frequency-band characteristics related to brain damage, expanded the cognitive neuroimaging mechanism, and provided additional OSA neuroimaging markers.
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DOI：
10.1523/jneurosci.1239-18.2018
发表时间：
2018-12-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bonnici HM;Cheke LG;Green DAE;FitzGerald THMB;Simons JS
通讯作者：
Simons JS
影响因子：
5.6
作者：
Ayalon, Liat;Ancoli-Israel, Sonia;Drummond, Sean P. A.
通讯作者：
Drummond, Sean P. A.
影响因子：
5.6
作者：
Baril, Andree-Ann;Gagnon, Katia;Gosselin, Nadia
通讯作者：
Gosselin, Nadia
显性顶下小叶动静脉畸形切除后语言皮层和白质束的可塑性：功能磁共振成像和 DTI 联合研究
影响因子：
4.1
作者：
Jiao, Yuming;Lin, Fuxin;Zhao, Jizong
通讯作者：
Zhao, Jizong
影响因子：
4.3
作者：
Kapur, Vishesh K.;Auckley, Dennis H.;Harrod, Christopher G.
通讯作者：
Harrod, Christopher G.