Complement fragment C3a controls mutual cell attraction during collective cell migration.
Complement fragment C3a controls mutual cell attraction during collective cell migration.
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DOI：
10.1016/j.devcel.2011.10.012
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发表时间：
2011-12-13
影响因子：
11.8
通讯作者：
Mayor, Roberto
中科院分区：
文献类型：
--
作者：
Carmona-Fontaine, Carlos;Theveneau, Eric;Tzekou, Apostolia;Tada, Masazumi;Woods, Mae;Page, Karen M.;Parsons, Maddy;Lambris, John D.;Mayor, Roberto
集体细胞迁移是一种对形态发生和肿瘤转移至关重要的运动方式。然而，关于迁移细胞是如何集体协调的，人们知之甚少。在这里，我们证明了细胞间的相互吸引(这里称为共吸引)是维持迁移的间充质细胞的凝聚力所必需的。共吸引可以通过接触抑制和上皮向间充质转化等机制来抵消细胞自然分散的趋势。神经脊细胞通过补体片段C3a及其受体C3aR相互吸引，揭示了补体蛋白在脊椎动物早期发育中意想不到的作用。相互吸引的丧失会扰乱这些细胞的集体和协调运动。我们认为，共吸引和接触抑制协同作用，使细胞集体能够自组织并有效地对外部信号做出反应，如化学引诱剂和驱避剂。►神经脊(NC)细胞相互吸引(共吸引)►NC共吸引是由补体片段C3a及其受体C3aR介导的，►共吸引是迁移NC细胞群状行为所必需的►共吸引和接触抑制足以产生集体迁移
Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents. ► Neural crest (NC) cells mutually attract each other (coattraction) ► NC coattraction is mediated by the complement fragment C3a and its receptor C3aR ► Coattraction is required for the swarm-like behavior of migratory NC cells ► Coattraction and contact inhibition suffice to generate collective migration
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DOI：
10.1083/jcb.200912134
发表时间：
2010-05-17
期刊：
The Journal of cell biology
影响因子：
--
作者：
Stramer B;Moreira S;Millard T;Evans I;Huang CY;Sabet O;Milner M;Dunn G;Martin P;Wood W
通讯作者：
Wood W
影响因子：
11.8
作者：
Theveneau, Eric;Marchant, Lorena;Kuriyama, Sei;Gull, Mazhar;Moepps, Barbara;Parsons, Maddy;Mayor, Roberto
通讯作者：
Mayor, Roberto
影响因子：
5.3
作者：
Itoh, RE;Kurokawa, K;Matsuda, M
通讯作者：
Matsuda, M
影响因子：
64.5
作者：
RIDLEY, AJ;PATERSON, HF;HALL, A
通讯作者：
HALL, A
血管内皮生长因子（VEGF）调节体内颅神经rest迁移。
影响因子：
2.7
作者：
McLennan R;Teddy JM;Kasemeier-Kulesa JC;Romine MH;Kulesa PM
通讯作者：
Kulesa PM