Research of double emulsion formation and shell-thickness influence factors in a novel six-way junction microfluidic device
Research of double emulsion formation and shell-thickness influence factors in a novel six-way junction microfluidic device
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新型六路连接微流控装置双乳液形成及壳厚影响因素研究
DOI：
10.1016/j.colsurfa.2020.124917
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Dongfang Sun
中科院分区：
文献类型：
--
作者：
Shiyao Tan;Cai Gao;Huanyu Liu;Bin Ye;Dongfang Sun
六路连接微流控装置已广泛用于制备薄壳双乳液作为脂质体的模板。但该装置中双乳液形成的数值研究较少，壳厚度的影响因素仍需进一步探讨。本文基于VOF方法进行数值模拟，研究六路连接微流控装置中双乳液的形成和壳厚度的影响因素。此外，还提出了一个新的概念，即相对壳厚度，以直观地反映壳厚度与液滴尺寸之间的关系。通过模拟，揭示了三种典型流态下的双乳液形成机制，包括滴落、窄化喷射和加宽喷射。讨论了操作参数对流态、双乳液液滴尺寸和壳厚度的影响。结果表明，毛细管数不仅影响流动状态，还影响液滴尺寸和壳厚度。还发现中间流体流量对壳厚度的影响大于外层流体流量，薄壳复乳液主要在滴落过程中产生。该文揭示了不同操作参数下壳层厚度的变化规律，可为六路连接微流控装置中制备壳层厚度可控的复乳液提供指导。
The six-way junction microfluidic device has been widely used to prepare thin-shelled double emulsions as templates for liposomes. However, there is little numerical research of double emulsion formation in this device, and the influence factors of shell thickness still need to be further explored. In this paper, numerical simulations based on the VOF method are conducted to investigate double emulsion formation and shell-thickness influence factors in the six-way junction microfluidic device. Moreover, a new concept named relative shell thickness is proposed to intuitively reflect the relationship between the shell thickness and drop size. By the simulations, the double emulsion formation mechanisms at three typical flow regimes are revealed, including dripping, narrowing jetting, and widening jetting. The effects of operation parameters on the flow regime, double-emulsion droplet size and shell thickness are discussed. Results indicate that capillary numbers not only affect the flow regime but also the droplet size and shell thickness. It also finds that the effect of the middle fluid flow rate on the shell thickness is larger than the outer fluid flow rate and that the thin-shelled double emulsions are mainly generated in dripping. This paper reveals the change law of shell thickness with varied operation parameters and can guide for preparing double emulsions with controllable shell thickness in the six-way junction microfluidic device.
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DOI：
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