An estimate of the number of human immunodeficiency virus (HIV)-positive blood donations by HIV-seronegative donors in a northern Thailand HIV epicenter.

An estimate of the number of human immunodeficiency virus (HIV)-positive blood donations by HIV-seronegative donors in a northern Thailand HIV epicenter.
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对泰国北部艾滋病毒震中的艾滋病毒血清阴性献血者的人类免疫缺陷病毒 (HIV) 阳性献血人数的估计。

DOI:
10.1093/infdis/174.4.870
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发表时间:
1996
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Nelson,KE
Nelson,KE
中科院分区:
--
文献类型:
--
作者:
Sawanpanyalert,P;Yanai,H;Kitsuwannakul,S;Nelson,KE

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尽管强制进行抗体检测,但人类免疫缺陷病毒(HIV)可以从血清阴性的HIV感染血液中传播。这项研究的目的是估计泰国北部HIV中心在血清阴性的“窗口期”内献血感染HIV的可能性。因此,建立了重复献血者的回顾队列。假设艾滋病毒血清转换的概率在最后一次艾滋病毒阴性和第一次艾滋病毒阳性捐赠之间均匀分布,并且血清阴性窗口为45天,通过将发病率乘以窗口持续时间来计算窗口期间的捐赠率。在11,232名重复捐赠者中,有273人在9,518,863个人日的观察期间血清转换(即窗口期的捐献率为1/775)。在21至30岁的男性中,有更多的人在窗口期献血,并且献血者取代了朋友或亲戚的血液。需要采取更多措施来减少受艾滋病毒感染的窗口期捐赠的大量数量。
Despite mandatory antibody testing, human immunodeficiency virus (HIV) can be transmitted from HIV-infected blood that is seronegative. The objective of this study was to estimate the probability of HIV-infected blood donations during the seronegative “window period” in a northern Thailand HIV epicenter. Thus, a retrospective cohort of repeat blood donors was created. With the assumptions that the probability of HIV seroconversion is distributed uniformly between the last HIV-negative and the first HIV-positive donation and that the seronegative window is 45 days, the rate of window-period donations was calculated by multiplying the incidence by the window duration. Of 11,232 repeat donors, 273 seroconverted during 9,518,863 person-days of observation (i.e., a window-period donation rate of 1/775). There were more window-period donations among 21- to 30-year-old men and in donors replacing blood of friends or relatives. Additional measures are needed to reduce the high number of HIV-infected window-period donations.
通过合并细胞的培养和 DNA 扩增对筛选献血的人类免疫缺陷病毒 1 型感染进行评估。
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影响因子: 158.5
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期刊: Transfusion
影响因子: 2.9
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影响因子: 2.9
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DOI: --
发表时间: 1994
期刊: AIDS (London)
影响因子: --
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