Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice.
Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice.
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DOI：
10.1016/j.neulet.2017.09.060
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发表时间：
2017-11-20
影响因子：
2.5
通讯作者：
Xia Z
中科院分区：
文献类型：
--
作者：
Engstrom AK;Xia Z
铅是一种神经毒物，对公众健康具有重大意义。流行病学研究表明，重金属暴露可能与认知能力下降的风险增加有关，但迄今为止，很少有研究评估成人铅暴露对动物模型认知行为的影响。在这里，我们将6周龄的雄性C57 BL/6小鼠暴露于0.2%的醋酸铅，从6周龄开始饮用水12周，然后评估海马依赖性空间记忆的缺陷和成年海马神经发生的损伤。在旷场试验中，铅未引起运动缺陷或焦虑。然而，我们发现，成人，亚慢性铅暴露足以导致空间短期记忆的赤字，这些赤字持续到至少2个月后铅暴露。此外，我们观察到，与对照组动物相比，铅处理的小鼠海马齿状回中成年出生的成熟神经元较少，这表明青春期和成年期的铅暴露可能会损害成年出生细胞的神经元分化。这些数据表明，成人铅暴露足以引起持续的空间短期记忆缺陷和损害成人海马神经发生的关键过程。
Lead is a neurotoxicant of immense public health importance. Epidemiology studies suggest that heavy metal exposure may be associated with an increased risk of cognitive decline, yet few studies to date have assessed the effect of adult lead exposure on cognitive behavior in animal models. Here, we exposed 6-week-old male C57BL/6 mice to 0.2% lead acetate via drinking water for 12 weeks starting at 6 weeks of age and then assessed for deficits in hippocampus-depending spatial memory and impairment of adult hippocampal neurogenesis. Lead did not cause locomotor deficits or anxiety in the open field test. However, we found that adult, subchronic lead exposure was sufficient to cause deficits in spatial short-term memory and these deficits persisted through at least 2 months post-lead exposure. Furthermore, we observed that lead-treated mice had fewer adult-born, mature neurons in the dentate gyrus of the hippocampus compared to control animals, suggesting that lead exposure during adolescence and adulthood may impair the neuronal differentiation of adult-born cells. These data suggest that adult lead exposure is sufficient to cause persistent deficits in spatial short-term memory and impair key processes in adult hippocampal neurogenesis.
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影响因子：
3.4
作者：
Bihaqi, Syed Waseem;Zawia, Nasser H.
通讯作者：
Zawia, Nasser H.
影响因子：
9.9
作者：
Stewart, W. F.;Schwartz, B. S.;Youssem, D.
通讯作者：
Youssem, D.
DOI：
10.1016/j.ijdevneu.2005.07.005
发表时间：
2005-11-01
影响因子：
1.8
作者：
Jaako-Movits, K;Zharkovsky, T;Zharkovsky, A
通讯作者：
Zharkovsky, A
影响因子：
3.4
作者：
Schneider, JS;Anderson, DW;Lidsky, TI
通讯作者：
Lidsky, TI
成人的海马牙齿颗粒细胞正在进行成熟，调节大脑中的学习和记忆。
DOI：
10.1523/jneurosci.3362-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Deng W;Saxe MD;Gallina IS;Gage FH
通讯作者：
Gage FH