OPN and αvβ3 expression are predictors of disease severity and worse prognosis in hepatocellular carcinoma.
OPN and αvβ3 expression are predictors of disease severity and worse prognosis in hepatocellular carcinoma.
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OPN 和 αvβ3 表达是肝细胞癌疾病严重程度和更差预后的预测因子
DOI：
10.1371/journal.pone.0087930
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li JP
中科院分区：
文献类型：
--
作者：
Jin Y;Chen JN;Feng ZY;Zhang ZG;Fan WZ;Wang Y;Li JP
Expressions of OPN and αvβ3 are associated with a poor prognosis in many malignancies. However, their relationship in hepatocellular carcinoma remains unclear. We systematically collected hepatocellular carcinoma tissue samples from 305 patients over 3 years, and analyzed the status of OPN and αvβ3 in hepatocellular carcinoma and correlate expression with patient disease status and survival outcome. Our study results indicated that OPN and αvβ3 are expressed at significantly higher rates in hepatocellular carcinoma compared with adjacent non-tumorous tissue (69.5% vs 18.4%, p<0.01 and 77.4% vs 21.6%, p<0.01, respectively). Both OPN and αvβ3 expression levels are associated with poor prognostic factors, including tumor size, capsular invasion, tumor thrombus of the portal vein, metastasis of the lymph node and clinical staging. Patients expressing OPN and αvβ3 had significantly shorter survival compared with patients negative for protein expression (p<0.01). Multivariate analysis also showed that both OPN and αvβ3 expression are independent prognostic factors for poorer survival in hepatocellular carcinoma. By this study, we conclude that OPN and αvβ3 are negative prognostic predictors in patients with hepatocellular carcinoma. The expressions of both OPN and αvβ3 are associated with worse survival outcome.
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影响因子：
3.7
作者：
Jin Y;Tong DY;Chen JN;Feng ZY;Yang JY;Shao CK;Li JP
通讯作者：
Li JP
DOI：
10.1186/bcr1398
发表时间：
2006
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Sloan EK;Pouliot N;Stanley KL;Chia J;Moseley JM;Hards DK;Anderson RL
通讯作者：
Anderson RL
影响因子：
6.4
作者：
Chetty, Chandramu;Lakka, Sajani S.;Bhoopathi, Praveen;Rao, Jasti S.
通讯作者：
Rao, Jasti S.
DOI：
10.1186/1756-9966-29-172
发表时间：
2010-12-30
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Chen RX;Xia YH;Xue TC;Ye SL
通讯作者：
Ye SL
DOI：
10.1016/j.jamcollsurg.2013.02.025
发表时间：
2013-07-01
影响因子：
5.2
作者：
Li, Neill Y.;Weber, Cynthia E.;Kuo, Paul C.
通讯作者：
Kuo, Paul C.