Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer.
Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer.
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骨桥蛋白、αvβ3 和 Pim-1 的过度表达与非小细胞肺癌中具有重要预后意义的临床病理变量相关。
DOI：
10.1371/journal.pone.0048575
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Li JP
中科院分区：
文献类型：
--
作者：
Jin Y;Tong DY;Chen JN;Feng ZY;Yang JY;Shao CK;Li JP
在本研究中，我们检测了骨桥蛋白 (OPN)、αvβ3 和 Pim-1 在非小细胞肺癌 (NSCLC) 中的表达，并研究了它们在 NSCLC 中表达模式的潜在临床意义。采用免疫组化方法检测208例NSCLC样本及其癌旁正常肺组织标本中OPN、αvβ3和Pim-1的蛋白表达。进行统计分析以评估 OPN、αvβ3 和 Pim-1 表达模式之间的关系及其与 NSCLC 患者临床病理参数的关联。 NSCLC组织中OPN、αvβ3和Pim-1表达阳性率分别为67.8%（141/208）、76.0%（158/208）和58.7%（122/208）。而在癌旁正常肺组织中，OPN、αvβ3和Pim-1的阳性率分别为20.2%（42/208）、24.0%（50/208）和14.9%（31/208）。 NSCLC与癌旁正常肺组织中OPN、αvβ3、Pim-1的阳性表达率差异均有统计学意义（P<0.01）。此外，OPN、αvβ3和Pim-1在NSCLC中的阳性表达与病理分级、淋巴结转移和临床分期晚期的升高相关（均P<0.01）。此外，在我们的 NSCLC 队列中还观察到 OPN 与 αvβ3、OPN 与 Pim-1、αvβ3 与 Pim-1 表达之间的关联（所有 P<0.01）。 OPN、αvβ3 和 Pim-1 蛋白在 NSCLC 中经常过表达，并且与一些已知对 NSCLC 预后具有重要意义的临床病理变量相关，表明它们可能在 NSCLC 的发生和/或进展中发挥重要作用。
In this study, we examined the expression of osteopontin (OPN), αvβ3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC. Immunohistochemical assays were used to examine the protein expression of OPN, αvβ3 and Pim-1 in 208 NSCLC samples and their adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the relationships between OPN, αvβ3 and Pim-1 expression patterns, and their association with the clinical-pathological parameters of NSCLC patients. In NSCLC tissues, the positive rates of OPN, αvβ3 and Pim-1 expression were 67.8% (141/208), 76.0% (158/208) and 58.7% (122/208), respectively. However, in the adjacent normal lung tissues, the positive rates of OPN, αvβ3 and Pim-1 were 20.2% (42/208), 24.0% (50/208) and 14.9% (31/208), respectively. The differences in the positive expression rates of OPN, αvβ3 and Pim-1 between NSCLCs and the adjacent normal lung tissues were all significant (P<0.01). Additionally, the positive expression of OPN, αvβ3 and Pim-1 in NSCLCs was associated with an increase in pathological grade, lymph node metastasis and advanced clinical stage (all P<0.01). Furthermore, associations between the expression of OPN and αvβ3, OPN and Pim-1, and αvβ3 and Pim-1 were also observed in our NSCLC cohort (all P<0.01). The OPN, αvβ3 and Pim-1 proteins are frequently overexpressed in NSCLC and are associated with some clinicopathologic variables that are of known prognostic importance in NSCLC, suggesting that they may play an important role in the development and/or progression of NSCLC.
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影响因子：
6.4
作者：
Chetty, Chandramu;Lakka, Sajani S.;Bhoopathi, Praveen;Rao, Jasti S.
通讯作者：
Rao, Jasti S.
影响因子：
5.3
作者：
Cui, Ri;Takahashi, Fumiyuki;Takahashi, Kazuhisa
通讯作者：
Takahashi, Kazuhisa
影响因子：
64.5
作者：
SENGER, DR;WIRTH, DF;HYNES, RO
通讯作者：
HYNES, RO
影响因子：
11.5
作者：
Coppola, D;Szabo, M;Yeatman, TJ
通讯作者：
Yeatman, TJ
影响因子：
11.2
作者：
Verbisck, Newton V.;Costa, Erico T.;Camargo, Anamaria A.
通讯作者：
Camargo, Anamaria A.