Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures.
Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures.
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DOI：
10.1002/jbmr.558
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发表时间：
2012-01
影响因子：
6.2
通讯作者：
Cummings, Steven R.
中科院分区：
文献类型：
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作者：
Hillier, Teresa A.;Lui, Li-Yung;Kado, Deborah M.;LeBlanc, E. S.;Vesco, Kimberly K.;Bauer, Douglas C.;Cauley, Jane A.;Ensrud, Kristine E.;Black, Dennis M.;Hochberg, Marc C.;Cummings, Steven R.
我们通过双能X线骨密度仪检测老年女性身高下降是否预示髋部骨折、其他非脊柱骨折和死亡率的风险，以及这种风险是否独立于椎骨骨折（VFx）和骨密度（BMD）。在骨质疏松性骨折研究的3,124名65岁及以上的女性中，我们评估了0年（1986-1988）和15年（2002-2004）之间测量的身高变化与随后经放射学证实的髋部骨折、其他非脊柱骨折的风险以及通过死亡证明评估的死亡率的相关性。每4个月对骨折和生命状态进行一次随访（>95%的联系完成）。考克斯比例风险模型评估了评估身高变化后（即最终身高测量后）平均5年内髋部骨折、非脊柱骨折和死亡率的风险。校正VFx、BMD和其他潜在协变量后，身高损失>5 cm与髋部骨折（HR 1.50，95% CI 1.06，2.12）、非脊柱骨折（HR 1.48; 95% CI 1.20，1.83）和死亡率（1.45; 95% CI 1.21，1.73）的风险显著增加相关。虽然主要分析是3，124名健康的幸存者的子集，足以返回进行第15年的身高测量，但使用成年早期的初始身高（25岁[-40岁]时自我报告的身高到>65岁[0岁]时测量的身高）对整个队列（n= 9，677）进行的敏感性分析显示了一致的结果。老年女性身高下降>5 cm（2”）与髋部骨折、非脊柱骨折和死亡率增加近50%相关，与VFx和BMD事件无关。
We examined if height loss in older women predicts risk of hip fractures, other non-spine fractures, and mortality, and whether this risk is independent of both vertebral fractures (VFx) and bone mineral density (BMD) by dual-energy x-ray absorptiometry. Among 3,124 women age 65 and older in the Study of Osteoporotic Fractures, we assessed the association with measured height change between Year 0 (1986–1988) and Year 15 (2002–2004) and subsequent risk of radiologically confirmed hip fractures, other non-spine fractures, and mortality assessed via death certificates. Follow-up occurred every 4 months for fractures and vital status (>95% contacts complete). Cox proportional hazards models assessed risk of hip fracture, non-spine fracture, and mortality over a mean of 5 years after height change was assessed (i.e, after final height measurement). After adjustment for VFx, BMD and other potential covariates, height loss >5 cm was associated with a marked increased risk of hip fracture (HR 1.50, 95% CI 1.06, 2.12), non-spine fracture (HR 1.48; 95% CI 1.20, 1.83), and mortality (1.45; 95% CI 1.21, 1.73). Although primary analyses were a subset of 3,124 survivors healthy enough to return for a Year 15 height measurement, a sensitivity analysis in the entire cohort (n=9,677) using initial height in earlier adulthood (self-reported height at age 25 [−40 years] to measured height age >65 years [Year 0]) demonstrated consistent results. Height loss >5 cm (2”) in older women was associated with a nearly 50% increased risk of hip fracture, non-spine fracture, and mortality—independent of incident VFx and BMD.
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影响因子：
39.2
作者：
Kado DM;Lui LY;Ensrud KE;Fink HA;Karlamangla AS;Cummings SR;Study of Osteoporotic Fractures
通讯作者：
Study of Osteoporotic Fractures
影响因子：
6.2
作者：
Moayyeri, Alireza;Luben, Robert N.;Khaw, Kay-Tee
通讯作者：
Khaw, Kay-Tee
影响因子：
6.1
作者：
Baron, YM;Brincat, MP;Calleja, N
通讯作者：
Calleja, N
影响因子：
--
作者：
Hillier, Teresa A.;Stone, Katie L.;Cummings, Steve R.
通讯作者：
Cummings, Steve R.
影响因子：
6.2
作者：
Black, DM;Arden, NK;Cummings, SR
通讯作者：
Cummings, SR