Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation.
Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation.
复制标题
对辐射引起的肺损伤进行建模：从整个胸腔照射中学到的经验教训。
DOI：
10.1080/09553002.2018.1532619
复制
发表时间：
2020-01
影响因子：
2.6
通讯作者：
Finkelstein JN
中科院分区：
文献类型：
--
作者：
Beach TA;Groves AM;Williams JP;Finkelstein JN
随着临床医生和科学家试图破译导致人类受试者在放射治疗后出现肺部毒性的事件，胸部照射模型已经开发出来。最常见的模型是单剂量的全胸部照射（WTI）。小鼠，特别是 C57BL/6J 品系，在这些研究中经常使用，并且极大地丰富了我们目前对放射性肺损伤 (RILI) 的发生和进展的理解。在这篇综述中，我们强调了 RILI 的顺序进展和动态性质，主要关注从小鼠模型中收集的大量信息。充足的证据表明，辐射后可以看到多种生物反应，包括 DNA 损伤、氧化应激、细胞衰老和炎症，所有这些都是由最初暴露于电离辐射 (IR) 引发的，并在整个损伤的时间进展过程中保持不均匀，表现为急性肺炎和后来的纤维化。似乎特定细胞类型的早期反应可能会促进进一步损伤，破坏微环境并阻止恢复稳态，尽管驱动这些反应的确切机制仍不清楚。通过针对这些不同的放射生物学过程，在临床前模型中预防或治疗 RILI 的尝试已取得了一些成功。随着我们通过使用此类模型对细胞对辐射的动态反应的理解不断加深，预防或治疗 RILI 的可能性也随之提高。
Models of thoracic irradiation have been developed as clinicians and scientists have attempted to decipher the events that led up to the pulmonary toxicity seen in human subjects following radiation treatment. The most common model is that of whole thorax irradiation (WTI), applied in a single dose. Mice, particularly the C57BL/6J strain, has been frequently used in these investigations, and has greatly informed our current understanding of the initiation and progression of radiation induced lung injury (RILI). In this review, we highlight the sequential progression and dynamic nature of RILI, focusing primarily on the vast array of information that has been gleaned from murine model. Ample evidence indicates a wide array of biological responses that can be seen following irradiation, including DNA damage, oxidative stress, cellular senescence and inflammation, all triggered by the initial exposure to ionizing radiation (IR) and heterogeneously maintained throughout the temporal progression of injury, which manifests as acute pneumonitis and later fibrosis. It appears that the early responses of specific cell types may promote further injury, disrupting the microenvironment and preventing a return to homeostasis, although the exact mechanisms driving these responses remains somewhat unclear. Attempts to either prevent or treat RILI in preclinical models have shown some success by targeting these disparate radiobiological processes. As our understanding of the dynamic cellular responses to radiation improves through the use of such models, so does the likelihood of preventing or treating RILI.
登录
查看更多内容
影响因子：
28.5
作者：
Ao X;Zhao L;Davis MA;Lubman DM;Lawrence TS;Kong FM
通讯作者：
Kong FM
TGFβ和PDGF信号传导的结合抑制减弱了辐射诱导的肺纤维化。
影响因子：
7.2
作者：
Dadrich M;Nicolay NH;Flechsig P;Bickelhaupt S;Hoeltgen L;Roeder F;Hauser K;Tietz A;Jenne J;Lopez R;Roehrich M;Wirkner U;Lahn M;Huber PE
通讯作者：
Huber PE
影响因子：
9.7
作者：
Azzam EI;Jay-Gerin JP;Pain D
通讯作者：
Pain D
影响因子：
4
作者：
Campisi, Judith
通讯作者：
Campisi, Judith
影响因子：
5.6
作者：
Baselet B;Belmans N;Coninx E;Lowe D;Janssen A;Michaux A;Tabury K;Raj K;Quintens R;Benotmane MA;Baatout S;Sonveaux P;Aerts A
通讯作者：
Aerts A