Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis).
Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis).
复制标题
树鼩体重、空腹血糖浓度、性别和年龄之间的关系。
DOI：
10.1111/jpn.12036
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发表时间：
2013-12
影响因子：
2.7
通讯作者：
Liang B
中科院分区：
文献类型：
--
作者：
Chen LL;Zhang LQ;Lv LB;Liang B
树鼩（Tupaia belangeri chinensis）是一种类松鼠的低等灵长类动物或灵长类动物的近亲，常被用作生物医学研究的动物模型。尽管在研究中使用了三十多年，但树鼩的体重、空腹血糖浓度、性别和年龄之间的明确关系仍不清楚。通过对992只4月龄~ 4月龄的树鼩（雄性454只，雌性538只）的调查，我们发现雄性树鼩的体重和空腹血糖浓度明显高于雌性树鼩（p < 0.001）。男性空腹血糖浓度随体重轻微升高（r = 0.152, p < 0.001）。与此同时，女性体重、空腹血糖浓度、腰围均随年龄的增长而增加（p < 0.001）。另外，17只Lee指数[体重(g)*0.33*1000/体长（cm）]大于290的树鼩，其体重、腰围和糖化血红蛋白A1c （HbA1c）均显著高于低于290的非肥胖树鼩（p < 0.001）。有趣的是，992只树鼩中有6只（雄性和雌性各3只，2-4岁）表现出血浆甘油三酯、糖化血红蛋白、低密度脂蛋白和口服糖耐量试验受损，提示代谢综合征的早期症状。本研究首次明确了树鼩体重、空腹血糖浓度、性别和年龄之间的关系，进一步提高了我们对代谢综合征（MetS）中这种关系的理解。考虑到树鼩与人类和非人类灵长类动物的相似性，这一发现支持了它们作为研究MetS的动物模型的潜在用途。
The tree shrew (Tupaia belangeri chinensis) is a squirrel-like lower primate or a close relative of primates, commonly used as an animal model in biomedical research. Despite more than three decades of usage in research, the clear relationships between body weight, fasting blood glucose concentration, sex and age among tree shrews remain unclear. Based on an investigation of 992 tree shrews (454 males and 538 females) aged between 4 months and 4 years old, we found that male tree shrews have significantly higher body weight and fasting blood glucose concentration than female tree shrews (p < 0.001). The concentration of fasting blood glucose slightly increased with body weight in males (r = 0.152, p < 0.001). Meanwhile, in females, the body weight, concentration of fasting blood glucose and waist circumference positively increased with age (p < 0.001). Additionally, 17 tree shrews with Lee index [body weight (g)*0.33*1000/body length (cm)] above 290 had significantly higher body weight, waist circumference and glycated haemoglobin A1c (HbA1c) than non-obese tree shrews with a Lee index score below 290 (p < 0.001). Interestingly, 6 of 992 tree shrews (three males and three females, 2-4 years old) displayed impaired plasma triglycerides, HbA1c, low-density lipoprotein and oral glucose tolerance test, suggestive of the early symptoms of metabolic syndrome. This study provides the first clear relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews, further improving our understanding of this relationship in metabolic syndrome (MetS). Given the similarity of tree shrews to humans and non-human primates, this finding supports their potential use as an animal model in the research of MetS.
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DOI：
10.1093/ajcn/79.1.31
发表时间：
2004
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
W. Pan;K. Flegal;Hsing-Yi Chang;W. Yeh;C. Yeh;Wen-Chung Lee
通讯作者：
W. Pan;K. Flegal;Hsing-Yi Chang;W. Yeh;C. Yeh;Wen-Chung Lee
DOI：
10.1016/s0021-5155(97)00073-7
发表时间：
1997-09
期刊：
Nippon Ganka Gakkai zasshi
影响因子：
--
作者：
S. Ishiko;A. Yoshida;F. Mori;T. Abiko;N. Kitaya;M. Kojima;K. Saito
通讯作者：
S. Ishiko;A. Yoshida;F. Mori;T. Abiko;N. Kitaya;M. Kojima;K. Saito
影响因子：
0.7
作者：
Cao, J;Yang, EB;Chow, P
通讯作者：
Chow, P
影响因子：
3.3
作者：
D. Muller;D. Elahi;J. Tobin;R. Andres
通讯作者：
D. Muller;D. Elahi;J. Tobin;R. Andres
DOI：
--
发表时间：
2007-03
期刊：
The Indian journal of medical research
影响因子：
--
作者：
K. Srinivasan;P. Ramarao
通讯作者：
K. Srinivasan;P. Ramarao