Shear wave dispersion measures liver steatosis.

Shear wave dispersion measures liver steatosis.
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DOI:
10.1016/j.ultrasmedbio.2011.10.019
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发表时间:
2012-02
影响因子:
2.9
通讯作者:
Parker, Kevin J.
Parker, Kevin J.
中科院分区:
医学3区
文献类型:
--
作者:
Barry, Christopher T.;Mills, Bradley;Hah, Zaegyoo;Mooney, Robert A.;Ryan, Charlotte K.;Rubens, Deborah J.;Parker, Kevin J.

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爬行波是干扰剪切波模式,可以在肝脏组织中在一定频率范围内产生。肝脏的一些重要的生物力学特性可以通过使用多普勒技术对爬行波进行成像并分析模式来确定。我们报告,剪切波速度和衰减的分散,即这些参数的频率依赖性,与小鼠肝脏模型中的脂肪变性程度,离体密切相关。结果表明,使用与彩色多普勒扫描仪兼容的非侵入性成像方法评估肝脏脂肪变性的可能性,此外,还表明,通过评估剪切波传播的色散或频率依赖性,可以将肝脏脂肪变性与纤维化分开。
Crawling waves, which are interfering shear wave patterns, can be generated in liver tissue over a range of frequencies. Some important biomechanical properties of the liver can be determined by imaging the crawling waves using Doppler techniques and analyzing the patterns. We report that the dispersion of shear wave velocity and attenuation, that is, the frequency dependence of these parameters, are strongly correlated with the degree of steatosis in a mouse liver model, ex vivo. The results demonstrate the possibility of assessing liver steatosis using noninvasive imaging methods that are compatible with color Doppler scanners and, furthermore, suggest that liver steatosis can be separated from fibrosis by assessing the dispersion or frequency dependence of shear wave propagations.
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