Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants.
Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants.
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新生儿重症监护室早产儿接触双酚A和其他酚类物质。
DOI：
10.1289/ehp.0800265
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发表时间：
2009-04
影响因子：
10.4
通讯作者：
Hauser, Russ
中科院分区：
文献类型：
--
作者：
Calafat, Antonia M.;Weuve, Jennifer;Ye, Xiaoyun;Jia, Lily T.;Hu, Howard;Ringer, Steven;Huttner, Ken;Hauser, Russ
我们先前证明，暴露于含有邻苯二甲酸二（2-乙基己基）酯（DEHP）的聚氯乙烯塑料医疗器械与两个新生儿重症监护病房的54名早产儿中几种DEHP代谢物的尿液浓度高于一般人群相关。对于其中42名婴儿，我们评估了与使用相同医疗器械相关的几种酚类（包括双酚A（BPA））的尿液浓度。我们测量了尿中BPA、三氯生、二苯甲酮-3、对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的游离和总（游离加结合）物质的浓度。在超过四分之三的早产儿中，双酚A以共轭形式存在的百分比> 90%。含DEHP产品的使用强度与BPA总浓度密切相关，但与任何其他苯酚无关。调整机构和性别后，高使用含DEHP产品组婴儿的BPA总浓度是低使用组婴儿的8.75倍（p < 0.0001）。同样，在调整性别和含DEHP产品使用类别后，机构A中婴儿的BPA总浓度是机构B中婴儿的16.6倍（p < 0.0001）。接受强化治疗性医疗干预的早产儿的BPA几何平均尿浓度（30.3 μg/L）比一般人群高一个数量级。结合物是BPA的主要尿液代谢物，这表明早产儿具有一定的代谢BPA的能力。不同含DEHP医疗产品使用强度的BPA暴露差异突出表明需要进一步研究以确定BPA暴露的具体来源。
We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants in two neonatal intensive care units than in the general population. For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices. We measured the urinary concentrations of free and total (free plus conjugated) species of BPA, triclosan, benzophenone-3, methyl paraben, and propyl paraben. The percentage of BPA present as its conjugated species was > 90% in more than three-quarters of the premature infants. Intensity of use of products containing DEHP was strongly associated with BPA total concentrations but not with any other phenol. Adjusting for institution and sex, BPA total concentrations among infants in the group of high use of DEHP-containing products were 8.75 times as high as among infants in the low use group (p < 0.0001). Similarly, after adjusting for sex and DEHP-containing product use category, BPA total concentrations among infants in Institution A were 16.6 times as high as those among infants in Institution B (p < 0.0001). BPA geometric mean urinary concentration (30.3 μg/L) among premature infants undergoing intensive therapeutic medical interventions was one order of magnitude higher than that among the general population. Conjugated species were the primary urinary metabolites of BPA, suggesting that premature infants have some capacity to metabolize BPA. The differences in exposure to BPA by intensity of use of DEHP-containing medical products highlight the need for further studies to determine the specific source(s) of exposure to BPA.
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DOI：
10.1159/000457587
发表时间：
1989-01-01
期刊：
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS
影响因子：
--
作者：
BURCHELL, B;COUGHTRIE, M;HUME, R
通讯作者：
HUME, R
影响因子：
10.4
作者：
Green R;Hauser R;Calafat AM;Weuve J;Schettler T;Ringer S;Huttner K;Hu H
通讯作者：
Hu H
影响因子：
10.4
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
通讯作者：
Needham LL
影响因子：
3.5
作者：
Della Seta, Daniele;Minder, Isabelle;Farabollini, Francesca
通讯作者：
Farabollini, Francesca
影响因子：
4.9
作者：
Jones, RD;Jampani, HB;Lee, AS
通讯作者：
Lee, AS