Urinary concentrations of triclosan in the U.S. population: 2003-2004.
Urinary concentrations of triclosan in the U.S. population: 2003-2004.
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DOI：
10.1289/ehp.10768
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发表时间：
2008-03
影响因子：
10.4
通讯作者：
Needham LL
中科院分区：
文献类型：
--
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
三氯生是一种具有广泛抗菌活性的合成化学品，已广泛用于消费品，包括个人护理产品、纺织品和塑料厨房用具。这项研究旨在评估2003年至2004年全国健康和营养检查调查(NANES)中6岁美国普通人群中具有代表性的样本≥三氯生的暴露情况。我们使用自动固相萃取结合同位素稀释-高效液相色谱-串联质谱仪分析了2517个尿样。在2.4~3,790μg/L范围内检测到总(游离+共轭)三氯生的浓度为74.6%，几何平均值为13.0μg/L(12.7μg/g肌酐)，第95百分位数为459.0μg/L(363.8μg/g肌酐)。我们观察到年龄与三氯生的调整最小二乘几何平均值(LSGM)浓度之间存在曲线关系。家庭收入高的人群中三氯生的LSGM浓度高于低收入(p<；0.01)和中等收入(p=0.04)类别的人群。在2003年至2004年NHANES分析的大约四分之三的尿样中，我们检测到了三氯生的浓度。集中度因年龄和社会经济地位而异，但不因种族/族裔和性别而异。具体地说，三氯生的浓度似乎在生命的第三个十年期间和家庭收入最高的人中最高。
Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware. This study was designed to assess exposure to triclosan in a representative sample ≥ 6 years of age of the U.S. general population from the 2003–2004 National Health and Nutrition Examination Survey (NHANES). We analyzed 2,517 urine samples using automated solid-phase extraction coupled to isotope dilution–high-performance liquid chromatography–tandem mass spectrometry. We detected concentrations of total (free plus conjugated) triclosan in 74.6% of samples at concentrations of 2.4–3,790 μg/L. The geometric mean and 95th percentile concentrations were 13.0 μg/L (12.7 μg/g creatinine) and 459.0 μg/L (363.8 μg/g creatinine), respectively. We observed a curvilinear relation between age and adjusted least square geometric mean (LSGM) concentrations of triclosan. LSGM concentrations of triclosan were higher in people in the high household income than in people in low (p < 0.01) and medium (p = 0.04) income categories. In about three-quarters of urine samples analyzed as part of NHANES 2003–2004, we detected concentrations of triclosan. Concentrations differed by age and socioeconomic status but not by race/ethnicity and sex. Specifically, the concentrations of triclosan appeared to be highest during the third decade of life and among people with the highest household incomes.
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