Diurnal cortisol patterns and psychiatric symptoms in pregnancy: short-term longitudinal study.
Diurnal cortisol patterns and psychiatric symptoms in pregnancy: short-term longitudinal study.
复制标题
妊娠的昼夜皮质醇模式和精神病症状：短期纵向研究。
DOI：
10.1016/j.biopsycho.2013.11.002
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发表时间：
2014-03
影响因子：
2.6
通讯作者：
Blackmore ER
中科院分区：
文献类型：
--
作者：
O'Connor TG;Tang W;Gilchrist MA;Moynihan JA;Pressman EK;Blackmore ER
HPA轴的改变是成年人焦虑和抑郁的一个强有力的生物标志物，但关于怀孕期间这种关联的问题仍然存在。我们研究了昼夜皮质醇和情绪症状之间的纵向联系，从自我报告问卷和诊断性访谈中的种族多样性，心理社会风险样本的101名妇女在怀孕中期和妊娠晚期早期。抑郁症和皮质醇升高之间存在适度但显著的相关性，以早晨水平降低和昼夜下降减少为指标;临床访谈的诊断数据的影响最强。这些影响独立于社会人口因素和睡眠障碍。与焦虑和创伤的关联一般不显着。这些发现扩展了先前的工作，表明怀孕期间的显著情绪症状与怀孕期间昼夜皮质醇的改变有关，这可能对孕产妇和儿童健康产生影响。
Alteration in the HPA axis is a robust biomarker of anxiety and depression in adults, but questions remain about this association in pregnancy. We examined the longitudinal links between diurnal cortisol and mood symptoms from self-report questionnaire and diagnostic interview in an ethnically diverse, psychosocially at-risk sample of 101 women at mid-pregnancy and early third trimester. There were modest but significant associations between depression and elevated cortisol, indexed by a decreased morning level and diminished diurnal decline; the effects were strongest for diagnostic data from clinical interview. These effects were independent of socio-demographic factors and sleep disturbance. Associations with anxiety and trauma were generally non-significant. These findings extend prior work by showing that significant mood symptoms in pregnancy are associated with altered diurnal cortisol in pregnancy, which may have implications for maternal and child health.
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影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
3.7
作者：
Kivlighan, Katie T.;DiPietro, Janet A.;Costigan, Kathleen A.;Laudenslager, Mark L.
通讯作者：
Laudenslager, Mark L.
影响因子：
3.1
作者：
Greenwood, Kenneth M;Hazendonk, Kim M
通讯作者：
Hazendonk, Kim M
影响因子：
168.9
作者：
Gitau, R;Cameron, A;Glover, V
通讯作者：
Glover, V
影响因子：
3.1
作者：
Bennett, GG;Merritt, MM;Wolin, KY
通讯作者：
Wolin, KY