Diurnal rhythm of cortisol during late pregnancy: associations with maternal psychological well-being and fetal growth.
Diurnal rhythm of cortisol during late pregnancy: associations with maternal psychological well-being and fetal growth.
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DOI：
10.1016/j.psyneuen.2008.06.008
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发表时间：
2008-10
影响因子：
3.7
通讯作者：
Laudenslager, Mark L.
中科院分区：
文献类型：
--
作者：
Kivlighan, Katie T.;DiPietro, Janet A.;Costigan, Kathleen A.;Laudenslager, Mark L.
怀孕期间母亲的心理功能会影响母亲和胎儿的健康。下丘脑-垂体-肾上腺（HPA）轴提供了一种机制，通过该机制可以将母亲的心理社会因素传递给胎儿。然而，很少有研究探讨母亲心理因素或出生结果与皮质醇昼夜模式的关系。目前的研究调查了 98 名低风险孕妇（51 名初产妇）的母亲心理健康状况、产次状况和出生体重与母亲皮质醇昼夜节律的关系。妊娠 36 周时，参与者完成了妊娠特异性和一般心理功能的自我报告测量，并在连续 2 个工作日的 800、1200 和 1600 小时提供唾液样本以进行皮质醇测定。观察到唾液皮质醇的预期每日下降。对于所有母亲来说，更高的特质焦虑与下午更平坦的下降有关。对于初产妇来说，早晨皮质醇下降幅度更大与婴儿出生体重较低有关。研究结果表明，HPA 轴的调节可能因胎次状态而异，并对胎儿生长和发育产生下游影响。
Maternal psychological functioning during pregnancy affects both maternal and fetal well-being. The hypothalamic-pituitary-adrenal (HPA) axis provides one mechanism through which maternal psychosocial factors may be transduced to the fetus. However, few studies have examined maternal psychological factors or birth outcomes in relation to the diurnal pattern of cortisol across the day. The current study examined maternal psychological well-being, parity status, and birth weight in relation to the maternal cortisol diurnal rhythm in a group of 98 low-risk pregnant women (51 primiparae). At 36 weeks gestation, participants completed both pregnancy-specific and general self-report measures of psychological functioning and provided saliva samples at 800, 1200, and 1600h on 2 consecutive working days for the assay of cortisol. The expected diurnal decline in salivary cortisol was observed. Higher trait anxiety was associated with a flatter afternoon decline for all mothers. For primiparae, steeper morning cortisol declines were associated with lower infant birth weight. The findings suggest that regulation of the HPA axis may differ by parity status with downstream implications for fetal growth and development.
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影响因子：
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作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
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