Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism.
Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism.
复制标题
癌症发动机的油：致癌信号传导和多胺代谢之间的串扰。
DOI：
10.1126/sciadv.aar2606
复制
发表时间：
2018-01
期刊：
影响因子：
13.6
通讯作者：
Carracedo A
中科院分区：
文献类型：
--
作者：
Arruabarrena-Aristorena A;Zabala-Letona A;Carracedo A
多胺代谢表现出与致癌信号的紧密串扰，因此在癌症动力学中起着核心作用。对代谢的研究提供了关于癌细胞的生物学基础和治疗弱点的重要信息。经典生物化学确立了代谢改变在肿瘤生物学中的重要性，并揭示了各种代谢物家族对肿瘤发生过程的重要性。从这些研究中，我们有证据表明多胺（小的多阳离子代谢物）在细胞增殖和癌症生长中的核心作用。然而，癌细胞如何激活这一代谢途径以及多胺致癌作用背后的分子线索在很大程度上仍然不清楚。与代谢物作为癌细胞燃料（合成代谢中间体）的观点相反，多胺更好地定义为润滑癌症发动机的油，因为它们影响生物过程的活性。现代研究使这种代谢途径重新成为人们关注的焦点，为癌症中的遗传、代谢和信号传导事件提供了强有力的联系。在这篇综述中，我们列举并讨论了目前的观点，多胺代谢的调节和活动在肿瘤细胞生物学。
Polyamine metabolism exhibits tight cross-talk with oncogenic signaling, thus playing a central role in cancer dynamics. The study of metabolism has provided remarkable information about the biological basis and therapeutic weaknesses of cancer cells. Classic biochemistry established the importance of metabolic alterations in tumor biology and revealed the importance of various metabolite families to the tumorigenic process. We have evidence of the central role of polyamines, small polycatonic metabolites, in cell proliferation and cancer growth from these studies. However, how cancer cells activate this metabolic pathway and the molecular cues behind the oncogenic action of polyamines has remained largely obscure. In contrast to the view of metabolites as fuel (anabolic intermediates) for cancer cells, polyamines are better defined as the oil that lubricates the cancer engine because they affect the activity of biological processes. Modern research has brought back to the limelight this metabolic pathway, providing a strong link between genetic, metabolic, and signaling events in cancer. In this review, we enumerate and discuss current views of the regulation and activity of polyamine metabolism in tumor cell biology.
登录
查看更多内容
影响因子：
4.8
作者：
Devens, BH;Weeks, RS;Brawer, MK
通讯作者：
Brawer, MK
影响因子：
--
作者：
Cullis, PM;Green, RE;Travis, N
通讯作者：
Travis, N
影响因子：
64.5
作者：
Delmore JE;Issa GC;Lemieux ME;Rahl PB;Shi J;Jacobs HM;Kastritis E;Gilpatrick T;Paranal RM;Qi J;Chesi M;Schinzel AC;McKeown MR;Heffernan TP;Vakoc CR;Bergsagel PL;Ghobrial IM;Richardson PG;Young RA;Hahn WC;Anderson KC;Kung AL;Bradner JE;Mitsiades CS
通讯作者：
Mitsiades CS
影响因子：
13.3
作者：
Chrisam M;Pirozzi M;Castagnaro S;Blaauw B;Polishchuck R;Cecconi F;Grumati P;Bonaldo P
通讯作者：
Bonaldo P
影响因子：
14.9
作者：
FRUGIER, M;FLORENTZ, C;GIEGE, R
通讯作者：
GIEGE, R