Role of macrophages in the candidacidal activity of liposomal amphotericin B.
Role of macrophages in the candidacidal activity of liposomal amphotericin B.
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巨噬细胞在脂质体两性霉素 B 念珠菌活性中的作用。
DOI：
10.1093/infdis/175.1.214
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Dulski,K
中科院分区：
文献类型：
--
作者：
Mehta,RT;Poddar,S;Kalidas,M;Gomez-Flores,R;Dulski,K
The role of macrophage activation in the candidacidal activity of liposome-incorporated (L) amphotericin B was investigated. Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with neither F-nor L-amphotericin B killed amphotericin B-resistant Can-dida tropicalis. In vivo stimulation of macrophages by intraperitoneal administration of thioglycol-late, Freund's complete adjuvant, or heat-killed C. albicans followed by in vitro treatment with F-or L-amphotericin B, did not enhance their candidacidal activity. Intravenous administration of F-or L-amphotericin B did not augment the candidacidal activity of macrophages sensitized in vivo; however, sensitized macrophages showed enhanced killing compared with resident unstimu-lated cells. These studies suggest that macrophage-mediated enhancement of C. albicans killing may be due to uptake, transport, and delivery of L-amphotericin B to infected sites rather than to macrophage activation.
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用脂质体两性霉素 B 治疗全身性真菌感染。
影响因子：
--
作者：
G. Lopez;G. Bodey;V. Fainstein;M. Keating;L. Frankel;B. Zeluff;L. Gentry;K. Mehta
通讯作者：
K. Mehta
脂质体封装的两性霉素 B (AmBisome) 和两性霉素 B-脱氧胆酸盐 (Fungizone) 对人多形核白细胞吞噬和念珠菌功能的体外影响。
DOI：
10.1093/jac/30.3.313
发表时间：
1992
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
C. Pallister;E. Johnson;D. Warnock;P. J. Elliot;D. Reeves
通讯作者：
D. Reeves
影响因子：
3.3
作者：
Reeta Mehta;Teresa Mcqueen;A. Keyhani;G. Lopez-Berestein
通讯作者：
Reeta Mehta;Teresa Mcqueen;A. Keyhani;G. Lopez-Berestein
脂质体作为多烯抗生素的药物载体
DOI：
--
发表时间：
1989
期刊：
影响因子：
--
作者：
R. Mehta
通讯作者：
R. Mehta
重组γ干扰素激活巨噬细胞念珠菌活性的机制
影响因子：
3.1
作者：
Koji Watanabe;K. Kagaya;Toshihiko Yamada;Yoshimura Fukazawa
通讯作者：
Yoshimura Fukazawa