Quantitation method of loss powers using commercial magnetic nanoparticles based on superparamagnetic behavior influenced by anisotropy for hyperthermia
Quantitation method of loss powers using commercial magnetic nanoparticles based on superparamagnetic behavior influenced by anisotropy for hyperthermia
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基于受热疗各向异性影响的超顺磁行为，使用商业磁性纳米粒子的损耗功率定量方法
DOI：
10.1016/j.jmmm.2021.168313
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发表时间：
2021
影响因子：
2.7
通讯作者：
Takemura Yasushi
中科院分区：
文献类型：
--
作者：
Ota Satoshi;Trisnanto Suko Bagus;Takeuchi Seiji;Wu Jiaojiao;Cheng Yu;Takemura Yasushi
使用磁性纳米颗粒的局部热疗作为一种侵入性较小的癌症治疗方法引起了人们的关注。准确估计磁性纳米粒子的散热对于热疗具有重要意义。在这项研究中，测量了Feraheme®、Resovist®和Syonomag®-D商用磁性纳米颗粒的磁化性能和散热。考虑各向异性的影响，用朗之万函数估算了有效岩心直径和各向异性常数。基于测量和磁弛豫理论，估计了假设的球形肿瘤中所需的磁场相对于磁性纳米颗粒的重量和浓度的频率和强度。介绍了一种通过测量磁性纳米颗粒的磁化特性来定量测量其在肿瘤组织中的真实散热的方法。由于磁性纳米粒子在肿瘤组织中的物理旋转被抑制，因此通过在实验样品中固化大量纳米粒子来估计实际的散热。根据磁化曲线的面积估算了磁性纳米粒子的比损耗功率和本征损耗功率。结果表明，只有磁化强度的线性分量与损耗功率有关。我们的损耗功率和外加磁场指数的量化方法将有助于磁性纳米颗粒热疗的临床应用。
Local hyperthermia using magnetic nanoparticles has attracted attention as a less invasive cancer therapy. Accurate estimation of heat dissipation of magnetic nanoparticles is important for hyperthermia treatment. In this study, the magnetization properties and heat dissipation of Feraheme®, Resovist®, and Synomag®-D commercial magnetic nanoparticles was measured. The effective core diameter and anisotropy constant were estimated by the Langevin function taking into consideration the effect of anisotropy. The required frequency and intensity of an applied magnetic field with respect to the weight and concentration of magnetic nanoparticles in an assumed spherical tumor were estimated based on measurement and theory of magnetic relaxation. A method to quantitate realistic heat dissipation of magnetic nanoparticles in tumor tissue by measurement of their magnetization properties is introduced. Because the physical rotation of magnetic nanoparticles is inhibited in tumor tissue, the realistic heat dissipation is estimated by solidifying a mass of nanoparticles in an experimental sample. The specific loss power and intrinsic loss power as the heat dissipations of magnetic nanoparticles were estimated from the area of the magnetization curves. The results indicated that only the linear component of magnetization was associated with the loss powers. Our method to quantitate loss powers and the index for applied magnetic field will facilitate the clinical application of hyperthermia treatment using magnetic nanoparticles.
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影响因子：
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