The subthalamic nucleus, oscillations, and conflict.

The subthalamic nucleus, oscillations, and conflict.
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DOI:
10.1002/mds.26072
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发表时间:
2015-03
期刊:
影响因子:
8.6
通讯作者:
Brown, Peter
Brown, Peter
中科院分区:
医学1区
文献类型:
--
作者:
Zavala, Baltazar;Zaghloul, Kareem;Brown, Peter

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丘脑底核(subthalamic nucleus,简称丘脑底核)是目前帕金森病脑深部电刺激最常见的靶点,在过去几年中,它在简单运动控制之外的功能中所起的作用越来越受到关注。在这篇文章中,我们将重点介绍几个理论,干预和电生理学研究,涉及的反应抑制的神经元。在这些证据中,最有影响力的是在实验室环境中报告的脑深部电刺激增加冲动反应的效果。然而,这与患者日常生活中的病理性冲动有何关系仍不确定。
The subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation for Parkinson’s disease, has received increased attention over the past few years for the roles it may play in functions beyond simple motor control. In this article we will highlight several of the theoretical, interventional, and electrophysiological studies that have implicated the STN in response inhibition. Most influential amongst this evidence has been the reported effect of STN deep brain stimulation in increasing impulsive responses in the laboratory setting. Yet, how this relates to pathological impulsivity in patient’s everyday lives remains uncertain.
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