APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study.
APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study.
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DOI：
10.1016/j.exger.2016.11.001
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发表时间：
2017-01
影响因子：
3.9
通讯作者：
Obisesan, Thomas O.
中科院分区：
文献类型：
--
作者：
Allard, Joanne S.;Ntekim, Oyonumo;Johnson, Steven P.;Ngwa, Julius S.;Bond, Vernon;Pinder, Dynell;Gillum, Richard F.;Fungwe, Thomas V.;Kwagyan, John;Obisesan, Thomas O.
载脂蛋白E（APOE）基因ε4等位基因的拥有是晚发性阿尔茨海默病（AD）最普遍的遗传危险因素。最近的证据表明，APOE基因型差异影响脑源性神经营养因子（BDNF）的表达。值得注意的是，有氧运动诱导的BDNF上调是有据可查的;运动已被证明可以改善认知功能。由于BDNF以其在神经可塑性和存活中的作用而闻名，因此其上调是体育锻炼的神经保护作用的一种机制。在这项旨在分析未充分研究人群中运动诱导的BDNF上调的初步研究中，我们检查了ApoEε4（ε4）携带状态对标准化运动计划后BDNF表达变化的影响。年龄在55岁及以上的非裔美国人，被诊断患有轻度认知障碍，参加了为期六个月的拉伸（对照治疗）或有氧（实验治疗）运动的监督计划。仅在男性参与者中检测到运动引起的VO 2 Max增加。采用ELISA法测定血清中BDNF水平。ε4携带者和非ε4携带者之间的年龄、筛选MMSE评分和BMI、VO 2 Max和BDNF的基线测量值没有差异。检测到ε4状态与血清BDNF水平之间存在显著相关性。非ε4携带者在6个月的时间点显示BDNF水平显著增加，而ε4携带者则没有。我们相信我们已经确定了ε4等位基因和BDNF对生理适应的反应之间的关系，这可能会影响从体育锻炼中获得的神经保护益处的程度。我们的研究结果的复制，包括不同的种族队列，和一个没有运动的对照组将是必要的，以确定在一般人群中的这种关联的范围。
Possession of the Apolipoprotein E (APOE) gene ε4 allele is the most prevalent genetic risk factor for late onset Alzheimer’s disease (AD). Recent evidence suggests that APOE genotype differentially affects the expression of brain-derived neurotrophic factor (BDNF). Notably, aerobic exercise-induced upregulation of BDNF is well documented; and exercise has been shown to improve cognitive function. As BDNF is known for its role in neuroplasticity and survival, its upregulation is a proposed mechanism for the neuroprotective effects of physical exercise. In this pilot study designed to analyze exercise-induced BDNF upregulation in an understudied population, we examined the effects of ApoEε4 (ε4) carrier status on changes in BDNF expression after a standardized exercise program. African Americans, age 55 years and older, diagnosed with mild cognitive impairment participated in a six-month, supervised program of either stretch (control treatment) or aerobic (experimental treatment) exercise. An exercise-induced increase in VO2Max was detected only in male participants. BDNF levels in serum were measured using ELISA. Age, screening MMSE scores and baseline measures of BMI, VO2Max, and BDNF did not differ between ε4 carriers and non-ε4 carriers. A significant association between ε4 status and serum BDNF levels was detected. Non-ε4 carriers showed a significant increase in BDNF levels at the 6 month time point while ε4 carriers did not. We believe we have identified a relationship between the ε4 allele and BDNF response to physiologic adaptation which likely impacts the extent of neuroprotective benefit gained from engagement in physical exercise. Replication of our results with inclusion of diverse racial cohorts, and a no-exercise control group will be necessary to determine the scope of this association in the general population.
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影响因子：
3.4
作者：
Berchtold, NC;Kesslak, JP;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
3.7
作者：
Chang L;Wang Y;Ji H;Dai D;Xu X;Jiang D;Hong Q;Ye H;Zhang X;Zhou X;Liu Y;Li J;Chen Z;Li Y;Zhou D;Zhuo R;Zhang Y;Yin H;Mao C;Duan S;Wang Q
通讯作者：
Wang Q
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
DOI：
10.1177/1073858410397054
发表时间：
2012-02
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Erickson KI;Miller DL;Roecklein KA
通讯作者：
Roecklein KA
影响因子：
4.8
作者：
Altenburg, Michael;Johnson, Lance;Maeda, Nobuyo
通讯作者：
Maeda, Nobuyo