The aging hippocampus: interactions between exercise, depression, and BDNF.
The aging hippocampus: interactions between exercise, depression, and BDNF.
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DOI：
10.1177/1073858410397054
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Roecklein KA
中科院分区：
文献类型：
--
作者：
Erickson KI;Miller DL;Roecklein KA
成年晚期与海马萎缩和功能障碍增加有关。虽然海马退化在晚年发生有多种途径，但作者讨论了脑源性神经营养因子（BDNF）基因的单核苷酸多态性和BDNF蛋白或受体表达的年龄相关变化导致海马萎缩的证据。作者得出结论，很少有研究测试BDNF是否介导年龄相关的海马萎缩和记忆障碍。然而，有强有力的证据表明，BDNF减少与年龄相关的海马功能障碍，记忆障碍和抑郁症的风险增加有关，而通过有氧运动增加BDNF似乎可以改善海马萎缩，改善记忆功能，减少抑郁症。重要的是，BDNF和海马功能障碍之间最一致的关联已经出现在啮齿动物BDNF蛋白表达和人类血清和血浆BDNF浓度的研究中。目前的研究表明，BDNF val66met多态性可能与成年晚期海马萎缩仅存在微弱相关性。这些结论解释与年龄相关的记忆障碍和预防海马萎缩。
Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy.
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影响因子：
2.9
作者：
Bruehl H;Wolf OT;Sweat V;Tirsi A;Richardson S;Convit A
通讯作者：
Convit A
影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
11.3
作者：
Karnik, Meghana S.;Wang, Lei;Barch, Deanna M.;Morris, John C.;Csernansky, John G.
通讯作者：
Csernansky, John G.
影响因子：
2.9
作者：
Erickson KI;Kim JS;Suever BL;Voss MW;Francis BM;Kramer AF
通讯作者：
Kramer AF