Red blood cell distribution width and the risk of death in middle-aged and older adults.
Red blood cell distribution width and the risk of death in middle-aged and older adults.
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DOI：
10.1001/archinternmed.2009.11
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发表时间：
2009-03-09
影响因子：
--
通讯作者：
Guralnik, Jack M.
中科院分区：
文献类型：
--
作者：
Patel, Kushang V.;Ferrucci, Luigi;Ershler, William B.;Longo, Dan L.;Guralnik, Jack M.
红细胞分布宽度（RDW）是电子全血细胞计数的一个组成部分，是循环红细胞大小异质性的量度。在有症状的心血管疾病（CVD）患者中，RDW与死亡率相关。然而，还没有证明RDW是独立于营养缺乏或在一般人群中的死亡率的预测因子。RDW是在一个全国性的样本中测量的8175名年龄在45岁及以上的社区居住的成年人，他们参加了1988-1994年全国健康和营养检查调查;死亡率随访发生到2000年12月31日。所有原因，心血管疾病，癌症和其他原因的死亡作为RDW的函数进行了检查。较高的RDW值与死亡风险增加密切相关。与RDW的最低五分位数相比，以下是全因死亡率的校正风险比（HR）（和95%置信区间）：第二个五分位数，1.1（0.9-1.3）;第三个五分位数，1.2（1.0-1.4）;第四个五分位数，1.4（1.2-1.8）;第五个五分位数，2.1（1.7-2.6）。RDW每增加1%，全因死亡风险就会增加22% [HR = 1.22（1.15-1.30）; p<0.001]。即使分析仅限于非贫血参与者或RDW正常范围（11-15%）且无铁、叶酸或维生素B12缺乏的参与者，RDW仍与死亡率密切相关。RDW的预后效果在中年和老年人中观察到多种死因。RDW是一种广泛使用的测试，是45岁及以上成年人一般人群死亡率的强有力预测因素。
Red cell distribution width (RDW), a component of an electronic complete blood count, is a measure of heterogeneity in the size of circulating erythrocytes. In patients with symptomatic cardiovascular disease (CVD), RDW is associated with mortality. However, it has not been demonstrated that RDW is a predictor of mortality independent of nutritional deficiencies or in the general population. RDW was measured in a national sample of 8175 community-dwelling adults aged 45 and older who participated in the 1988–1994 National Health and Nutrition Examination Survey; mortality follow-up occurred through December 31, 2000. Deaths from all causes, CVD, cancer, and other causes were examined as a function of RDW. Higher RDW values were strongly associated with an increased risk of death. Compared to the lowest quintile of RDW, the following were adjusted hazard ratios (HR) for all-cause mortality (and 95 percent confidence intervals): second quintile, 1.1 (0.9–1.3); third quintile, 1.2 (1.0–1.4); fourth quintile, 1.4 (1.2–1.8); fifth quintile, 2.1 (1.7–2.6). For every 1 percent increment in RDW, all-cause mortality risk increased by 22% [HR = 1.22 (1.15–1.30); p<0.001]. Even when analyses were restricted to non-anemic participants or to those in the normal range of RDW (11–15%) without iron, folate, or vitamin B12 deficiency, RDW remained strongly associated with mortality. The prognostic effect of RDW was observed in both middle-aged and older adults for multiple causes of death. RDW is a widely-available test that is a strong predictor of mortality in the general population of adults aged 45 and older.
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影响因子：
8.9
作者：
Garcez, ME;Peres, W;Salvador, M
通讯作者：
Salvador, M
DOI：
10.1097/00042737-200202000-00012
发表时间：
2002-02-01
影响因子：
2.1
作者：
Guidetti, CS;Scaglione, N;Martini, S
通讯作者：
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影响因子：
37.8
作者：
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通讯作者：
Cook, Nancy R.
影响因子：
120.7
作者：
Looker, AC;Dallman, PR;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
39.2
作者：
Levey, Andrew S.;Coresh, Josef;Van Lente, Frederick
通讯作者：
Van Lente, Frederick