Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Behavioral and biological results.
Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Behavioral and biological results.
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氯米帕明和氟西汀治疗强迫症的对照比较。
DOI：
10.1001/archpsyc.1990.01810220042005
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发表时间：
1990
影响因子：
--
通讯作者：
D. Murphy
中科院分区：
文献类型：
--
作者：
T. Pigott;M. Pato;S. Bernstein;G. Grover;J. L. Hill;T. Tolliver;D. Murphy
采用两种不同的实验设计，比较盐酸氟西汀和盐酸氯丙咪嗪治疗两组强迫症患者的疗效。在第一组11名强迫症患者中，采用随机、双盲、交叉设计进行研究，发现氟西汀治疗10周产生的治疗效果与氯丙咪嗪治疗10周相似。氟西汀治疗期间报告的总副作用明显少于氯丙咪嗪治疗。在4周的交叉间隔期内逐渐减少药物和安慰剂替代导致强迫症症状和抑郁症的大量复发。此外，对第二种药物的反应与对第一种药物的反应一样长，尽管这两种药物被认为是通过共同的机制起作用，即血清素摄取抑制。第二组21例强迫症患者，既往接受氯丙咪嗪治疗稳定，至少部分获益，以双盲方式交叉至氟西汀治疗。氟西汀给药10周后，大多数患者表现出的强迫症和抑郁症状的行为评分与氯丙咪嗪治疗期间完成的交叉前评分相当。在第二个强迫症患者队列中，还观察到强迫症和抑郁评分显著加重以及治疗疗效类似滞后。在氯丙咪嗪和氟西汀治疗期间，血小板5-HT浓度降低95%。这些结果表明，氟西汀可能是一个可行的替代氯丙咪嗪在治疗强迫症，虽然需要更大的样本量进一步研究。
Treatment with fluoxetine hydrochloride was compared with treatment with clomipramine hydrochloride in two groups of patients with obsessive-compulsive disorder using two different experimental designs. In the first group of 11 patients with obsessive-compulsive disorder studied using a randomized, double-blind, crossover design, treatment with fluoxetine for 10 weeks was found to produce therapeutic effects similar to treatment with clomipramine for 10 weeks. There were significantly fewer total side effects reported during fluoxetine than clomipramine treatment. Drug tapering and placebo substitution in the 4-week crossover interval phase led to substantial relapses in obsessive-compulsive disorder symptoms and depression. Furthermore, responses to the second drug took as long to occur as responses to the first drug, although both drugs are thought to act by a common mechanism, serotonin uptake inhibition. A second group of 21 patients with obsessive-compulsive disorder that had been previously stabilized on clomipramine treatment with at least partial benefit were crossed over to fluoxetine treatment in a double-blind fashion. After 10 weeks of fluoxetine administration, most patients manifested behavioral rating scores of obsessive-compulsive disorder and depressive symptoms that were comparable with precrossover ratings completed during clomipramine treatment. A significant exacerbation in obsessive-compulsive disorder and depression ratings as well as a similar lag in therapeutic efficacy were also noted in this second cohort of patients with obsessive-compulsive disorder. Platelet 5-HT concentrations were reduced 95% during both clomipramine and fluoxetine treatment periods. These results suggest that fluoxetine may represent a viable alternative to clomipramine in the treatment of obsessive-compulsive disorder, although further studies with larger sample sizes are needed.
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强迫症患者停用氯米帕明后症状恢复。
DOI：
10.1176/ajp.145.12.1521
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Pato,MT;Zohar-Kadouch,R;Zohar,J;Murphy,DL
通讯作者：
Murphy,DL
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
影响因子：
--
作者：
Charney,DS;Goodman,WK;Price,LH;Woods,SW;Rasmussen,SA;Heninger,GR
通讯作者：
Heninger,GR
氟伏沙明治疗强迫症的功效。
影响因子：
--
作者：
Goodman,WK;Price,LH;Rasmussen,SA;Delgado,PL;Heninger,GR;Charney,DS
通讯作者：
Charney,DS
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney