Differential dendritic remodeling in prelimbic cortex of male and female rats during recovery from chronic stress.
Differential dendritic remodeling in prelimbic cortex of male and female rats during recovery from chronic stress.
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DOI：
10.1016/j.neuroscience.2017.05.049
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发表时间：
2017-08-15
期刊：
影响因子：
3.3
通讯作者：
Wellman CL
中科院分区：
文献类型：
--
作者：
Moench KM;Wellman CL
慢性应激引起雄性和雌性大鼠内侧前额叶皮质锥体神经元的不同树突重塑。在男性中，这种树突重塑是可逆的。然而，恢复的时间轴以及雌性动物的可逆性潜力尚不清楚。在这里，我们研究了树突状恢复锥体神经元在第二-第二层的边缘前皮质在雄性和雌性大鼠慢性束缚应激（3小时/天，10天）。在停止应激后立即或在7或10天恢复期后分析树突形态和棘密度。慢性压力产生的男性，这是再加上顶端树突上的棘的密度下降的顶端树突的树突退缩。此外，经过10天的恢复期后，应激大鼠的神经元形态与未应激大鼠相似。与未应激大鼠相比，给予7天恢复期的雄性大鼠具有顶端树突生长。在停止应激后，女性仅表现出最小的树突重塑。应激雌性大鼠的神经元形态与未应激大鼠的神经元形态相似，仅恢复7天后，此时棘突密度也显著增加。恢复期间，雄性和雌性动物的基线皮质酮浓度也显示出不同的变化。这些结果不仅表明，在边缘前皮质的树突重塑后，慢性应激是男性和女性之间的不同，但也表明慢性应激诱导不同的下丘脑-垂体-肾上腺轴失调的男性和女性。这些差异可能对后续压力源的反应有重要影响。
Chronic stress produces differential dendritic remodeling of pyramidal neurons in medial prefrontal cortex of male and female rats. In males, this dendritic remodeling is reversible. However, the timeline of recovery, as well as the potential for reversibility in females, is unknown. Here, we examined dendritic recovery of pyramidal neurons in layer II–II of prelimbic cortex in male and female rats following chronic restraint stress (3 h/day for 10 days). Dendritic morphology and spine density were analyzed immediately following the cessation of stress, or following a 7 or 10 day recovery period. Chronic stress produced apical dendritic retraction in males, which was coupled with a decrease in the density of stubby spine on apical dendrites. Further, following a 10-day recovery period, the morphology of neurons from stressed rats resembled that of unstressed rats. Male rats given a 7 day recovery period had apical dendritic outgrowth compared to unstressed rats. Immediately after cessation of stress, females showed only minimal dendritic remodeling. The morphology of neurons in stressed females resembled those of unstressed rats following only 7 days of recovery, at which time there was also a significant increase in stubby spine density. Males and females also showed different changes in baseline corticosterone concentrations during recovery. These findings not only indicate that dendritic remodeling in prelimbic cortex following chronic stress is different between males and females, but also suggest chronic stress induces differential hypothalamic-pituitary-adrenal axis dysregulation in males and females. These differences may have important implications for responses to subsequent stressors.
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DOI：
10.1523/jneurosci.0759-10.2010
发表时间：
2010-05-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bloss EB;Janssen WG;McEwen BS;Morrison JH
通讯作者：
Morrison JH
影响因子：
5.5
作者：
Grudt, TJ;Perl, ER
通讯作者：
Perl, ER
影响因子：
2.9
作者：
Beck, KD;Luine, VN
通讯作者：
Luine, VN
影响因子：
10.5
作者：
CARROLL, BJ
通讯作者：
CARROLL, BJ
DOI：
10.1073/pnas.0908563106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Hains, Avis Brennan;Vu, Mai Anh T.;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.