Alterations in cutaneous immune reactivity to dinitrofluorobenzene in graying C57BL/vi.vi mice.
Alterations in cutaneous immune reactivity to dinitrofluorobenzene in graying C57BL/vi.vi mice.
复制标题
变灰 C57BL/vi.vi 小鼠皮肤对二硝基氟苯的免疫反应性的变化。
DOI：
10.1111/1523-1747.ep12354989
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Nordlund,JJ
中科院分区：
文献类型：
--
作者：
Rheins,LA;Palkowski,MR;Nordlund,JJ
C57 BL/vi.vi小鼠的皮毛在6周龄时为黑色。到6月龄时，动物为白色，表皮或毛球内无可识别的色素细胞。患有白癜风的人类受试者表现出表皮色素细胞的损失。白癜风患者色素细胞的丧失与皮肤对接触性过敏原的免疫反应性丧失有关。因此，进行研究以确定这些脱色小鼠中色素细胞的损失是否也与皮肤免疫应答的损失相关。在脱色之前、期间和之后，定量背部和耳朵上的Ia阳性（Ia +）朗格汉斯细胞（LC）/mm 2的数量，所述部位是用二硝基氟苯（DNFB）致敏和激发的部位。我们观察到灰化小鼠在色素丧失前后背部和耳部的LC/mm ~ 2均低于正常对照C57 BL/6小鼠。年轻的有色C57 BL/vi.vi小鼠能够发展为中度接触性超敏反应;老年的脱色小鼠对DNFB不敏感。我们的结论是，脱色小鼠，像人类受试者白癜风，有一个损失的接触超敏反应与损失的色素细胞内的表皮。在小鼠中，黑素细胞的损失与Ia +细胞群体密度的降低有关。
The fur of the C57BL/vi.vi mouse is black at 6 weeks of age. By 6 months of age the animals are white and there are no identifiable pigment cells within the epidermis or hair bulbs. Human subjects with vitiligo exhibit loss of epidermal pigment cells. The loss of pigment cells in human subjects with vitiligo has been associated with loss of cutaneous immune reactivity to contact allergens. Therefore, studies were performed to determine whether loss of pigment cells in these depigmenting mice also was associated with loss of the cutaneous immune response. The number of Ia-positive (Ia +) Langerhans cells (LC)/mm2on the back and the ear, the sites of sensitization and challenge with dinitrofluorobenzene (DNFB), was quantified before, during, and after depigmentation. We observed that there were fewer LC/mm2on the back and the ear before and after pigment loss in the graying mice than in the normal control C57BL/6 mice. The young pigmented C57BL/vi.vi mice were capable of developing moderate contact hypersensitivity; the older depigmented mice did not sensitize to DNFB. We conclude that the depigmented mice, like human subjects with vitiligo, have a loss of contact hypersensitivity associated with a loss of pigment cells within the epidermis. In the mouse, loss of melanocytes is associated with a decrease in the population density of Ia + cells.
登录
查看更多内容
一种定量人和鼠皮肤表皮层中朗格汉斯细胞的方法。
影响因子：
--
作者：
J. Nordlund;A. Ackles
通讯作者：
A. Ackles
在接触性过敏反应中单核细胞与朗格汉斯细胞的结合。
影响因子：
3.6
作者：
I. Silberberg
通讯作者：
I. Silberberg
朗格汉斯细胞和白癜风：T6 和 HLA-DR 抗原表达细胞的定量研究。
影响因子：
3.6
作者：
A. Claudy;B. Rouchouse
通讯作者：
B. Rouchouse
可识别表皮朗格汉斯细胞群体密度的调节与皮肤免疫反应性的增强或抑制相关。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rheins,LA;Nordlund,JJ
通讯作者：
Nordlund,JJ
携带 Ia 的表皮朗格汉斯细胞的免疫功能。
影响因子：
4.4
作者：
G. Stingl;Stephen I. Katz;L. Clement;Ira Green;E. Shevach
通讯作者：
E. Shevach