Advances in mosquito repellents: effectiveness of citronellal derivatives in laboratory and field trials.
Advances in mosquito repellents: effectiveness of citronellal derivatives in laboratory and field trials.
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DOI：
10.1002/ps.7127
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发表时间：
2022-12
影响因子：
4.1
通讯作者：
Dani, Francesca Romana
中科院分区：
文献类型：
--
作者：
Iovinella, Immacolata;Caputo, Beniamino;Cobre, Pietro;Manica, Mattia;Mandoli, Alessandro;Dani, Francesca Romana
包括香茅油（柠檬草、香茅属、禾本科）在内的多种精油是众所周知的驱蚊剂。此类产品的缺点是其活性成分的高挥发性导致其保护时间有限。特别是，香茅油的保护时间<2小时，尽管含有固定剂的配方可以延长这个时间。我们合成了香茅主要成分香茅醛的羟基化环状缩醛，得到了挥发性较低、气味较弱的衍生物。在实验室条件下测试了反应中获得的异构体粗混合物对两种蚊子（主要疟疾病媒冈比亚按蚊和虫媒病毒载体白纹伊蚊）的驱避性，发现对相同浓度的 DEET（N,N-二乙基间甲苯酰胺）具有更长的防护时间。配方产品在白纹伊蚊高密度区域进行了拉丁方人体现场试验，测试时间为施用后 8 小时。我们发现，香茅醛衍生物混合物的性能与最广泛使用的合成驱虫剂避蚊胺和埃卡瑞丁的性能相当（在 ≤3.5 小时内提供 95% 的保护），并在四倍高剂量下进行测试。改变天然驱虫剂的亲水性和挥发性是设计具有持久效果的驱虫剂的一个有价值的策略。 © 2022 作者。 《害虫管理科学》由 John Wiley & Sons Ltd 代表化学工业协会出版。羟基化环状缩醛混合物由香茅醛与甘油缩合而成，经过测试其驱蚊性能，与避蚊胺相比显示出更持久的保护作用。
Several essential oils, including citronella (lemongrass, Cymbopogon sp., Poaceae), are well‐known mosquito repellents. A drawback of such products is their limited protection time resulting from the high volatility of their active components. In particular, citronella oil protects for <2 h, although formulations with fixatives can increase this time. We synthesized hydroxylated cyclic acetals of citronellal, the main component of citronella, to obtain derivatives with lower volatility and weaker odour. The crude mixture of isomers obtained in the reaction was tested under laboratory conditions for its repellency against two mosquito species, the major malaria vector Anopheles gambiae and the arbovirus vector Aedes albopictus, and found to be endowed with longer protection time with respect to DEET (N,N‐diethyl‐meta‐toluamide) at the same concentration. Formulated products were tested in a latin square human field trial, in an area at a high density of A. albopictus for 8 h from the application. We found that the performance of the citronellal derivatives mixture is comparable (95% protection for ≤3.5 h) with those of the most widespread synthetic repellents DEET and Icaridin, tested at a four‐fold higher doses. Modifying the hydrophilicity and volatility of natural repellents is a valuable strategy to design insect repellents with a long‐lasting effect. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. The mixture of hydroxylated cyclic acetals, obtained from condensation of citronellal with glycerol, was tested for its repellency against mosquitoes and showed a longer‐lasting protection in comparison to DEET.
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影响因子：
3.6
作者：
Gottlieb, HE;Kotlyar, V;Nudelman, A
通讯作者：
Nudelman, A
影响因子：
3
作者：
Killeen GF;Govella NJ;Lwetoijera DW;Okumu FO
通讯作者：
Okumu FO
影响因子：
4.1
作者：
Samarasekera, Radhika;Weerasinghe, Indira S.;Hemalal, K. D. Patrick
通讯作者：
Hemalal, K. D. Patrick
DOI：
10.18052/www.scipress.com/ijppe.8.54
发表时间：
2017-01-01
期刊：
International Journal of Pharmacology, Phytochemistry and Ethnomedicine
影响因子：
--
作者：
Bhat, K. S.;Aravind, G.
通讯作者：
Aravind, G.
影响因子：
3.2
作者：
Stefanidesova, Katarina;Skultety, L'udovit;Spitalska, Eva
通讯作者：
Spitalska, Eva