Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.

't Hart, Leen M.;Fritsche, Andreas;Diamant, Michaela

Morris, Andrew P.;Voight, Benjamin F.;Teslovich, Tanya M.;Ferreira, Teresa;Segre, Ayellet V.;Steinthorsdottir, Valgerdur;Strawbridge, Rona J.;Khan, Hassan;Grallert, Harald;Mahajan, Anubha;Prokopenko, Inga;Kang, Hyun Min;Dina, Christian;Esko, Tonu;Fraser, Ross M.;Kanoni, Stavroula;Kumar, Ashish;Lagou, Vasiliki;Langenberg, Claudia;Luan, Jian'an;Lindgren, Cecilia M.;Mueller-Nurasyid, Martina;Pechlivanis, Sonali;Rayner, N. William;Scott, Laura J.;Wiltshire, Steven;Yengo, Loic;Kinnunen, Leena;Rossin, Elizabeth J.;Raychaudhuri, Soumya;Johnson, Andrew D.;Dimas, Antigone S.;Loos, Ruth J. F.;Vedantam, Sailaja;Chen, Han;Florez, Jose C.;Fox, Caroline;Liu, Ching-Ti;Rybin, Denis;Couper, David J.;Kao, Wen Hong L.;Li, Man;Cornelis, Marilyn C.;Kraft, Peter;Sun, Qi;van Dam, Rob M.;Stringham, Heather M.;Chines, Peter S.;Fischer, Krista;Fontanillas, Pierre;Holmen, Oddgeir L.;Hunt, Sarah E.;Jackson, Anne U.;Kong, Augustine;Lawrence, Robert;Meyer, Julia;Perry, John R. B.;Platou, Carl G. P.;Potter, Simon;Rehnberg, Emil;Robertson, Neil;Sivapalaratnam, Suthesh;Stancakova, Alena;Stirrups, Kathleen;Thorleifsson, Gudmar;Tikkanen, Emmi;Wood, Andrew R.;Almgren, Peter;Atalay, Mustafa;Benediktsson, Rafn;Bonnycastle, Lori L.;Burtt, Noel;Carey, Jason;Charpentier, Guillaume;Crenshaw, Andrew T.;Doney, Alex S. F.;Dorkhan, Mozhgan;Edkins, Sarah;Emilsson, Valur;Eury, Elodie;Forsen, Tom;Gertow, Karl;Gigante, Bruna;Grant, George B.;Groves, Christopher J.;Guiducci, Candace;Herder, Christian;Hreidarsson, Astradur B.;Hui, Jennie;James, Alan;Jonsson, Anna;Rathmann, Wolfgang;Klopp, Norman;Kravic, Jasmina;Krjutskov, Kaarel;Langford, Cordelia;Leander, Karin;Lindholm, Eero;Lobbens, Stephane;Mannisto, Satu;Mirza, Ghazala;Muehleisen, Thomas W.;Musk, Bill;Parkin, Melissa;Rallidis, Loukianos;Saramies, Jouko;Sennblad, Bengt;Shah, Sonia;Sigurdsson, Gunnar;Silveira, Angela;Steinbach, Gerald;Thorand, Barbara;Trakalo, Joseph;Veglia, Fabrizio;Wennauer, Roman;Winckler, Wendy;Zabaneh, Delilah;Campbell, Harry;van Duijn, Cornelia;Uitterlinden, Andre G.;Hofman, Albert;Sijbrands, Eric;Abecasis, Goncalo R.;Owen, Katharine R.;Zeggini, Eleftheria;Trip, Mieke D.;Forouhi, Nita G.;Syvanen, Ann-Christine;Eriksson, Johan G.;Peltonen, Leena;Noethen, Markus M.;Balkau, Beverley;Palmer, Colin N. A.;Lyssenko, Valeriya;Tuomi, Tiinamaija;Isomaa, Bo;Hunter, David J.;Qi, Lu;Shuldiner, Alan R.;Roden, Michael;Barroso, Ines;Wilsgaard, Tom;Beilby, John;Hovingh, Kees;Price, Jackie F.;Wilson, James F.;Rauramaa, Rainer;Lakka, Timo A.;Lind, Lars;Dedoussis, George;Njolstad, Inger;Pedersen, Nancy L.;Khaw, Kay-Tee;Wareham, Nicholas J.;Keinanen-Kiukaanniemi, Sirkka M.;Saaristo, Timo E.;Korpi-Hyovalti, Eeva;Saltevo, Juha;Laakso, Markku;Kuusisto, Johanna;Metspalu, Andres;Collins, Francis S.;Mohlke, Karen L.;Bergman, Richard N.;Tuomilehto, Jaakko;Boehm, Bernhard O.;Gieger, Christian;Hveem, Kristian;Cauchi, Stephane;Froguel, Philippe;Baldassarre, Damiano;Tremoli, Elena;Humphries, Steve E.;Saleheen, Danish;Danesh, John;Ingelsson, Erik;Ripatti, Samuli;Salomaa, Veikko;Erbel, Raimund;Joeckel, Karl-Heinz;Moebus, Susanne;Peters, Annette;Illig, Thomas;de Faire, Ulf;Hamsten, Anders;Morris, Andrew D.;Donnelly, Peter J.;Frayling, Timothy M.;Hattersley, Andrew T.;Boerwinkle, Eric;Melander, Olle;Kathiresan, Sekar;Nilsson, Peter M.;Deloukas, Panos;Thorsteinsdottir, Unnur;Groop, Leif C.;Stefansson, Kari;Hu, Frank;Pankow, James S.;Dupuis, Josee;Meigs, James B.;Altshuler, David;Boehnke, Michael;McCarthy, Mark I.

Scott, Robert A.;Lagou, Vasiliki;Welch, Ryan P.;Wheeler, Eleanor;Montasser, May E.;Luan, Jian'an;Maegi, Reedik;Strawbridge, Rona J.;Rehnberg, Emil;Gustafsson, Stefan;Kanoni, Stavroula;Rasmussen-Torvik, Laura J.;Yengo, Loic;Lecoeur, Cecile;Shungin, Dmitry;Sanna, Serena;Sidore, Carlo;Johnson, Paul C. D.;Jukema, J. Wouter;Johnson, Toby;Mahajan, Anubha;Verweij, Niek;Thorleifsson, Gudmar;Hottenga, Jouke-Jan;Shah, Sonia;Smith, Albert V.;Sennblad, Bengt;Gieger, Christian;Salo, Perttu;Perola, Markus;Timpson, Nicholas J.;Evans, David M.;St Pourcain, Beate;Wu, Ying;Andrews, Jeanette S.;Hui, Jennie;Bielak, Lawrence F.;Zhao, Wei;Horikoshi, Momoko;Navarro, Pau;Isaacs, Aaron;O'Connell, Jeffrey R.;Stirrups, Kathleen;Vitart, Veronique;Hayward, Caroline;Esko, Tonu;Mihailov, Evelin;Fraser, Ross M.;Fall, Tove;Voight, Benjamin F.;Raychaudhuri, Soumya;Chen, Han;Lindgren, Cecilia M.;Morris, Andrew P.;Rayner, Nigel W.;Robertson, Neil;Rybin, Denis;Liu, Ching-Ti;Beckmann, Jacques S.;Willems, Sara M.;Chines, Peter S.;Jackson, Anne U.;Kang, Hyun Min;Stringham, Heather M.;Song, Kijoung;Tanaka, Toshiko;Peden, John F.;Goel, Anuj;Hicks, Andrew A.;An, Ping;Mueller-Nurasyid, Martina;Franco-Cereceda, Anders;Folkersen, Lasse;Marullo, Letizia;Jansen, Hanneke;Oldehinkel, Albertine J.;Bruinenberg, Marcel;Pankow, James S.;North, Kari E.;Forouhi, Nita G.;Loos, Ruth J. F.;Edkins, Sarah;Varga, Tibor V.;Hallmans, Goeran;Oksa, Heikki;Antonella, Mulas;Nagaraja, Ramaiah;Trompet, Stella;Ford, Ian;Bakker, Stephan J. L.;Kong, Augustine;Kumari, Meena;Gigante, Bruna;Herder, Christian;Munroe, Patricia B.;Caulfield, Mark;Antti, Jula;Mangino, Massimo;Small, Kerrin;Miljkovic, Iva;Liu, Yongmei;Atalay, Mustafa;Kiess, Wieland;James, Alan L.;Rivadeneira, Fernando;Uitterlinden, Andre G.;Palmer, Colin N. A.;Doney, Alex S. F.;Willemsen, Gonneke;Smit, Johannes H.;Campbell, Susan;Polasek, Ozren;Bonnycastle, Lori L.;Hercberg, Serge;Dimitriou, Maria;Bolton, Jennifer L.;Fowkes, Gerard R.;Kovacs, Peter;Lindstrom, Jaana;Zemunik, Tatijana;Bandinelli, Stefania;Wild, Sarah H.;Basart, Hanneke V.;Rathmann, Wolfgang;Grallert, Harald;Maerz, Winfried;Kleber, Marcus E.;Boehm, Bernhard O.;Peters, Annette;Pramstaller, Peter P.;Province, Michael A.;Borecki, Ingrid B.;Hastie, Nicholas D.;Rudan, Igor;Campbell, Harry;Watkins, Hugh;Farrall, Martin;Stumvoll, Michael;Ferrucci, Luigi;Waterworth, Dawn M.;Bergman, Richard N.;Collins, Francis S.;Tuomilehto, Jaakko;Watanabe, Richard M.;de Geus, Eco J. C.;Penninx, Brenda W.;Hofman, Albert;Oostra, Ben A.;Psaty, Bruce M.;Vollenweider, Peter;Wilson, James F.;Wright, Alan F.;Hovingh, G. Kees;Metspalu, Andres;Uusitupa, Matti;Magnusson, Patrik K. E.;Kyvik, Kirsten O.;Kaprio, Jaakko;Price, Jackie F.;Dedoussis, George V.;Deloukas, Panos;Meneton, Pierre;Lind, Lars;Boehnke, Michael;Shuldiner, Alan R.;van Duijn, Cornelia M.;Morris, Andrew D.;Toenjes, Anke;Peyser, Patricia A.;Beilby, John P.;Koerner, Antje;Kuusisto, Johanna;Laakso, Markku;Bornstein, Stefan R.;Schwarz, Peter E. H.;Lakka, Timo A.;Rauramaa, Rainer;Adair, Linda S.;Smith, George Davey;Spector, Tim D.;Illig, Thomas;de Faire, Ulf;Hamsten, Anders;Gudnason, Vilmundur;Kivimaki, Mika;Hingorani, Aroon;Keinanen-Kiukaanniemi, Sirkka M.;Saaristo, Timo E.;Boomsma, Dorret I.;Stefansson, Kari;van der Harst, Pim;Dupuis, Josee;Pedersen, Nancy L.;Sattar, Naveed;Harris, Tamara B.;Cucca, Francesco;Ripatti, Samuli;Salomaa, Veikko;Mohlke, Karen L.;Balkau, Beverley;Froguel, Philippe;Pouta, Anneli;Jarvelin, Marjo-Riitta;Wareham, Nicholas J.;Bouatia-Naji, Nabila;McCarthy, Mark I.;Franks, Paul W.;Meigs, James B.;Teslovich, Tanya M.;Florez, Jose C.;Langenberg, Claudia;Ingelsson, Erik;Prokopenko, Inga;Barroso, Ines

Voight BF;Kang HM;Ding J;Palmer CD;Sidore C;Chines PS;Burtt NP;Fuchsberger C;Li Y;Erdmann J;Frayling TM;Heid IM;Jackson AU;Johnson T;Kilpeläinen TO;Lindgren CM;Morris AP;Prokopenko I;Randall JC;Saxena R;Soranzo N;Speliotes EK;Teslovich TM;Wheeler E;Maguire J;Parkin M;Potter S;Rayner NW;Robertson N;Stirrups K;Winckler W;Sanna S;Mulas A;Nagaraja R;Cucca F;Barroso I;Deloukas P;Loos RJ;Kathiresan S;Munroe PB;Newton-Cheh C;Pfeufer A;Samani NJ;Schunkert H;Hirschhorn JN;Altshuler D;McCarthy MI;Abecasis GR;Boehnke M