Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
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DOI：
10.1038/ng.2383
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发表时间：
2012-09
期刊：
影响因子：
30.8
通讯作者：
McCarthy, Mark I.
中科院分区：
文献类型：
--
作者：
Morris, Andrew P.;Voight, Benjamin F.;Teslovich, Tanya M.;Ferreira, Teresa;Segre, Ayellet V.;Steinthorsdottir, Valgerdur;Strawbridge, Rona J.;Khan, Hassan;Grallert, Harald;Mahajan, Anubha;Prokopenko, Inga;Kang, Hyun Min;Dina, Christian;Esko, Tonu;Fraser, Ross M.;Kanoni, Stavroula;Kumar, Ashish;Lagou, Vasiliki;Langenberg, Claudia;Luan, Jian'an;Lindgren, Cecilia M.;Mueller-Nurasyid, Martina;Pechlivanis, Sonali;Rayner, N. William;Scott, Laura J.;Wiltshire, Steven;Yengo, Loic;Kinnunen, Leena;Rossin, Elizabeth J.;Raychaudhuri, Soumya;Johnson, Andrew D.;Dimas, Antigone S.;Loos, Ruth J. F.;Vedantam, Sailaja;Chen, Han;Florez, Jose C.;Fox, Caroline;Liu, Ching-Ti;Rybin, Denis;Couper, David J.;Kao, Wen Hong L.;Li, Man;Cornelis, Marilyn C.;Kraft, Peter;Sun, Qi;van Dam, Rob M.;Stringham, Heather M.;Chines, Peter S.;Fischer, Krista;Fontanillas, Pierre;Holmen, Oddgeir L.;Hunt, Sarah E.;Jackson, Anne U.;Kong, Augustine;Lawrence, Robert;Meyer, Julia;Perry, John R. B.;Platou, Carl G. P.;Potter, Simon;Rehnberg, Emil;Robertson, Neil;Sivapalaratnam, Suthesh;Stancakova, Alena;Stirrups, Kathleen;Thorleifsson, Gudmar;Tikkanen, Emmi;Wood, Andrew R.;Almgren, Peter;Atalay, Mustafa;Benediktsson, Rafn;Bonnycastle, Lori L.;Burtt, Noel;Carey, Jason;Charpentier, Guillaume;Crenshaw, Andrew T.;Doney, Alex S. F.;Dorkhan, Mozhgan;Edkins, Sarah;Emilsson, Valur;Eury, Elodie;Forsen, Tom;Gertow, Karl;Gigante, Bruna;Grant, George B.;Groves, Christopher J.;Guiducci, Candace;Herder, Christian;Hreidarsson, Astradur B.;Hui, Jennie;James, Alan;Jonsson, Anna;Rathmann, Wolfgang;Klopp, Norman;Kravic, Jasmina;Krjutskov, Kaarel;Langford, Cordelia;Leander, Karin;Lindholm, Eero;Lobbens, Stephane;Mannisto, Satu;Mirza, Ghazala;Muehleisen, Thomas W.;Musk, Bill;Parkin, Melissa;Rallidis, Loukianos;Saramies, Jouko;Sennblad, Bengt;Shah, Sonia;Sigurdsson, Gunnar;Silveira, Angela;Steinbach, Gerald;Thorand, Barbara;Trakalo, Joseph;Veglia, Fabrizio;Wennauer, Roman;Winckler, Wendy;Zabaneh, Delilah;Campbell, Harry;van Duijn, Cornelia;Uitterlinden, Andre G.;Hofman, Albert;Sijbrands, Eric;Abecasis, Goncalo R.;Owen, Katharine R.;Zeggini, Eleftheria;Trip, Mieke D.;Forouhi, Nita G.;Syvanen, Ann-Christine;Eriksson, Johan G.;Peltonen, Leena;Noethen, Markus M.;Balkau, Beverley;Palmer, Colin N. A.;Lyssenko, Valeriya;Tuomi, Tiinamaija;Isomaa, Bo;Hunter, David J.;Qi, Lu;Shuldiner, Alan R.;Roden, Michael;Barroso, Ines;Wilsgaard, Tom;Beilby, John;Hovingh, Kees;Price, Jackie F.;Wilson, James F.;Rauramaa, Rainer;Lakka, Timo A.;Lind, Lars;Dedoussis, George;Njolstad, Inger;Pedersen, Nancy L.;Khaw, Kay-Tee;Wareham, Nicholas J.;Keinanen-Kiukaanniemi, Sirkka M.;Saaristo, Timo E.;Korpi-Hyovalti, Eeva;Saltevo, Juha;Laakso, Markku;Kuusisto, Johanna;Metspalu, Andres;Collins, Francis S.;Mohlke, Karen L.;Bergman, Richard N.;Tuomilehto, Jaakko;Boehm, Bernhard O.;Gieger, Christian;Hveem, Kristian;Cauchi, Stephane;Froguel, Philippe;Baldassarre, Damiano;Tremoli, Elena;Humphries, Steve E.;Saleheen, Danish;Danesh, John;Ingelsson, Erik;Ripatti, Samuli;Salomaa, Veikko;Erbel, Raimund;Joeckel, Karl-Heinz;Moebus, Susanne;Peters, Annette;Illig, Thomas;de Faire, Ulf;Hamsten, Anders;Morris, Andrew D.;Donnelly, Peter J.;Frayling, Timothy M.;Hattersley, Andrew T.;Boerwinkle, Eric;Melander, Olle;Kathiresan, Sekar;Nilsson, Peter M.;Deloukas, Panos;Thorsteinsdottir, Unnur;Groop, Leif C.;Stefansson, Kari;Hu, Frank;Pankow, James S.;Dupuis, Josee;Meigs, James B.;Altshuler, David;Boehnke, Michael;McCarthy, Mark I.
为了扩展对2型糖尿病（T2D）遗传结构和分子基础的理解，我们对Metabochip上的遗传变异进行了荟萃分析，涉及34，840例病例和114，981例对照，绝大多数是欧洲血统。我们确定了10个以前未报道的T2D易感基因座，包括两个显示性别差异的关联。这些数据的全基因组分析与进一步常见变异基因座的长尾一致，解释了T2D易感性的大部分变化。对扩大的易感基因座集的探索涉及糖尿病发病机制中的几个过程，包括CREBBB相关转录、脂肪细胞因子信号传导和细胞周期调节。
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis.
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影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
Ioannidis JP;Patsopoulos NA;Evangelou E
通讯作者：
Evangelou E