Nuciferine reduced fat deposition by controlling triglyceride and cholesterol concentration in broiler chickens.
Nuciferine reduced fat deposition by controlling triglyceride and cholesterol concentration in broiler chickens.
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荷叶碱通过控制肉鸡的甘油三酯和胆固醇浓度来减少脂肪沉积
DOI：
10.1016/j.psj.2020.09.013
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发表时间：
2020-12
期刊：
影响因子：
4.4
通讯作者：
Xie Z
中科院分区：
文献类型：
--
作者：
Zhou Y;Chen Z;Lin Q;Yang Y;Hang Y;Zhou X;Wu C;Xie Z
本研究旨在探讨荷叶碱对肉鸡脂代谢的影响。选用1日龄肉鸡120只，分为基础日粮组(正常对照组，添加荷花碱0 mg/kg)和荷花碱组，分别饲喂荷花碱25 mg/kg、100 mg/kg、400 mg/kg，连续42d，结果表明，荷叶碱能显著降低1日龄肉用仔鸡的体重、日增重、绝对和相对脂肪及肝脏重量。补充荷叶碱组大鼠血浆三碘甲状腺原氨酸、游离三碘甲状腺原氨酸、甲状腺素和游离甲状腺素浓度显著降低，而血浆胰高血糖素浓度显著升高。荷包牡丹碱组血浆和肝脏甘油三酯(TG)和总胆固醇(TC)浓度显著降低，而血浆和肝脏非酯化脂肪酸浓度、肝脂酶活性和肝糖原含量显著升高。肝组织学检查显示，100和400 mg/kg组大鼠脂肪细胞体积和大小均小于NC组。补充荷包牡丹碱可减轻肝脏脂肪变性。荷包牡丹碱组脂肪细胞体积缩小，体积缩小。荷叶碱显著降低了HMGCR、SREBP2、Acc和SPEBP-1C的基因表达水平，显著提高了LXR-α、CyP7A1和CPT-I的基因表达水平。结果表明，荷叶碱具有较强的降低脂肪沉积的活性，不仅表现为降低甘油三酯和总胆固醇的浓度，还表现为降低HMGCR、SREBP2、ACC和SPEBP-1c的关键基因表达水平，提高LXR-α、CyP7A1和CPT-I的关键基因表达水平。综上所述，荷包牡丹碱通过调节脂肪代谢减少肉鸡脂肪沉积的能力与甘油三酯和总胆固醇浓度的平衡有关。
The purpose of this study was to investigate whether dietary nuciferine affects lipid metabolism in broiler chickens. Four treatment groups were made from 120 1-day-old broiler chickens including the base diet group (normal control [NC], supplemented with 0 mg/kg of nuciferine) and groups treated with 25 mg/kg, 100 mg/kg, and 400 mg/kg of dietary nuciferine, which was supplemented for 42 d. The results showed that body weight, average daily weight gain, and absolute and relative fat and liver weight were significantly decreased with nuciferine supplementation. The plasma concentration of triiodothyronine, free triiodothyronine, thyroxine, and free thyroxine was significantly decreased in the nuciferine-supplemented group, but the plasma glucagon concentration was significantly increased. The plasma and hepatic triglyceride (TG) and total cholesterol (TC) concentrations were significantly decreased in the nuciferine group, but plasma and hepatic nonesterified fatty acid concentration, hepatic lipase activity, and hepatic glycogen content were significantly increased. Hepatic histological examination showed that fat cell volume and size in the 100 and 400 mg/kg group were smaller than those in the NC group. The fatty degeneration in the liver was decreased with nuciferine supplementation. The fat cell volume and size were shrunk in the nuciferine group. Dietary nuciferine supplementation significantly decreased the gene expression level of HMGCR, SREBP2, ACC, and SPEBP-1C, but significantly increased the gene expression level of LXR-α, CYP7A1, and CPT-I. The results indicated that nuciferine exhibited strong reduced fat deposition activities and reflected not only by decrease of the concentration of TG and TC but also by reduction in the key gene expression level of HMGCR, SREBP2, ACC, and SPEBP-1c and elevation of the key gene expression level of LXR-α, CYP7A1, and CPT-I. Taken together, our results suggested that the ability of nuciferine on reducing fat deposition in broiler chickens by regulating lipid metabolism was associated with the balance of TG and TC concentration.
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影响因子：
3.5
作者：
Kim, Yun Jung;Kim, Keun-Young;Park, Taesun
通讯作者：
Park, Taesun
荷叶碱可预防仓鼠高脂肪饮食引起的肝脏脂肪变性和损伤
影响因子：
3.7
作者：
Guo F;Yang X;Li X;Feng R;Guan C;Wang Y;Li Y;Sun C
通讯作者：
Sun C
影响因子：
4.4
作者：
Alagawany, M.;Abd El-Hack, M. E.;Swelum, A. A.
通讯作者：
Swelum, A. A.
影响因子：
2.1
作者：
Hornick, JL;Van Eenaeme, C;Istasse, L
通讯作者：
Istasse, L
影响因子：
6.1
作者：
Bursill, CA;Roach, PD
通讯作者：
Roach, PD