pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping.
pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping.
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DOI：
10.1016/j.jneumeth.2012.12.012
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发表时间：
2013-02-15
影响因子：
3
通讯作者：
Optican, Lance M.
中科院分区：
文献类型：
--
作者：
Daye, Pierre M.;Monosov, Ilya E.;Hikosaka, Okihide;Leopold, David A.;Optican, Lance M.
神经生理学家希望将电极的尖端放置在大脑的特定区域。该区域的坐标可以从标准立体定位地图集中获得。然而，个体的大脑可能与图谱并不完全一致。此外，对于慢性录音，电极被放置在动物头骨上的一个腔室里。因此，用户想要知道感兴趣的区域在房间坐标中的位置，而不是立体坐标。在腔室连接后，通常会进行MRI检查。这有助于电极放置，因为靶相对于腔室的位置可以根据图谱确定。然而，在实践中这样做需要粗略的估计或繁琐的计算。pyElectrode提供图形显示并执行必要的计算，以在立体定向和腔室坐标之间进行转换，从而促进基于mr的植入腔室靶向。它还允许实验者在实验过程中可视化记录或刺激点。最后，它可以以适合出版的格式在MRI切片背景上显示和输出这些站点。
Neurophysiogists want to place the tip of an electrode in a specific area of the brain. The coordinates of this area can be obtained from standard stereotaxic atlases. However, individual brains may not align with the atlas exactly. Additionally, for chronic recordings, electrodes are placed through a chamber attached to the animal's skull. Thus, the user wants to know where the area of interest is in chamber coordinates, not stereotaxic coordinates. After the chamber has been attached an MRI is often made. This assists in electrode placement, as the location of a target relative to the chamber can be determined based on the atlas. However, doing this in practice requires rough estimation or cumbersome calculations. pyElectrode provides a graphical display and performs calculations necessary to convert between stereotaxic and chamber coordinates, thus facilitating MR-based targeting from an implanted chamber. It also allows the experimenter to visualize recording or stimulation sites during experiments. Finally, it can display and output those sites on an MRI slice background in a format suitable for publication.
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作者：
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