Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.
Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.
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DOI：
10.3389/fnmol.2017.00333
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发表时间：
2017
影响因子：
4.8
通讯作者：
Zurzolo C
中科院分区：
文献类型：
--
作者：
Ariazi J;Benowitz A;De Biasi V;Den Boer ML;Cherqui S;Cui H;Douillet N;Eugenin EA;Favre D;Goodman S;Gousset K;Hanein D;Israel DI;Kimura S;Kirkpatrick RB;Kuhn N;Jeong C;Lou E;Mailliard R;Maio S;Okafo G;Osswald M;Pasquier J;Polak R;Pradel G;de Rooij B;Schaeffer P;Skeberdis VA;Smith IF;Tanveer A;Volkmann N;Wu Z;Zurzolo C
细胞间通信对于蜂窝网络和多蜂窝系统的组织、协调和发展至关重要。细胞间的通讯是由可溶性因子(包括生长因子、神经递质和细胞因子/趋化因子)、缝隙连接、外切体和最近描述的隧道纳米管(TNTs)介导的。目前尚不清楚TNTs和缝隙连接等这些通信机制的组合是否重要，但需要进一步研究。TNTs是一种长的细胞质桥梁，能够在连接的细胞之间实现远程、定向的通信。被提议的TNTs的功能是多样的，但并不是很清楚，但已经被证明包括囊泡、细胞器、电刺激和小分子的细胞间转移。然而，TNTs和缝隙连接在细胞间通讯中的确切作用及其对疾病的影响仍然不确定，因此，这是一个很有争议的主题。来自众多实验室的综合数据表明，一些TNT介导了与传染病、遗传、代谢、癌症和年龄相关的疾病有关的长距离缝隙连接通讯，以协调新陈代谢和信号传递。这篇综述旨在描述当前的知识、挑战和未来的前景，以表征和探索这一新的细胞间通讯系统，并设计基于TNT的治疗策略。
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.
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影响因子：
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作者：
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