Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer risk.
Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer risk.
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DOI：
10.1038/bjc.2013.184
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发表时间：
2013-05-14
影响因子：
8.8
通讯作者：
Sung FC
中科院分区：
文献类型：
--
作者：
Hung SC;Lai SW;Tsai PY;Chen PC;Wu HC;Lin WH;Sung FC
亚洲男性前列腺癌的发病率比西方男性低得多。本研究调查了低发病率人群中前列腺癌是否与前列腺炎、良性前列腺增生（BPH）和其他疾病相关。从台湾全民健康保险的理赔数据中，我们确定了1184例1997年至2008年诊断为前列腺癌的患者。对照组包括从无癌症人群中随机选择的4736名男性。两组均为50岁或以上。比较两组患者的病史。多因素Logistic回归分析显示前列腺炎和BPH与前列腺癌的相关性强于其他疾病。与无前列腺炎和BPH的男性相比，前列腺癌与BPH相关的比值比（OR）（26.2，95%置信区间（CI）20.8-33.0）高于前列腺炎（10.5，95% CI=3.36-32.7）。两种情况的男性的OR为49.2（95% CI=34.7-69.9）。患有前列腺癌的男性与前列腺炎和/或BPH有很强的关联。前列腺炎与BPH相互作用，导致患有这两种疾病的男性患前列腺癌的估计相对风险较高。
The incidence of prostate cancer is much lower in Asian men than in Western men. This study investigated whether prostate cancer is associated with prostatitis, benign prostatic hyperplasia (BPH), and other medical conditions in the low-incidence population. From the claims data obtained from the universal National Health Insurance of Taiwan, we identified 1184 patients with prostate cancer diagnosed from 1997 to 2008. Controls comprised 4736 men randomly selected from a cancer-free population. Both groups were 50 years of age or above. Medical histories between the two groups were compared. Multivariate logistic regression analysis showed that prostatitis and BPH had stronger association with prostate cancer than the other medical conditions tested. Compared with men without prostatitis and BPH, a higher odds ratio (OR) for prostate cancer was associated with BPH (26.2, 95% confidence interval (CI) 20.8–33.0) than with prostatitis (10.5, 95% CI=3.36–32.7). Men with both conditions had an OR of 49.2 (95% CI=34.7–69.9). Men with prostate cancer have strong association with prostatitis and/or BPH. Prostatitis interacts with BPH, resulting in higher estimated relative risk of prostate cancer in men suffering from both conditions.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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