Cytomegalovirus hijacks CX3CR1(hi) patrolling monocytes as immune-privileged vehicles for dissemination in mice.
Cytomegalovirus hijacks CX3CR1(hi) patrolling monocytes as immune-privileged vehicles for dissemination in mice.
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DOI：
10.1016/j.chom.2014.02.002
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发表时间：
2014-03-12
影响因子：
30.3
通讯作者：
Mocarski ES
中科院分区：
文献类型：
--
作者：
Daley-Bauer LP;Roback LJ;Wynn GM;Mocarski ES
外周血粒单核细胞对于巨细胞病毒传播到唾液腺等远端器官很重要，在这些器官中，持续的复制和脱落决定了传播模式。我们发现，小鼠巨细胞病毒(MCMV)编码的CC趋化因子MCK2显著增强了这一过程，MCK2促进CX3CR1hi巡逻单核细胞到小鼠初始感染部位的募集。在那里，这些细胞被感染，并通过血液流向远端部位。相比之下，炎性单核细胞，另一种主要的单核细胞亚群，仍然是病毒阴性。CX3CR1缺乏阻止了巡逻的单核细胞在血管内皮细胞上的迁移，并阻断了MCMV在唾液腺的传播，而不依赖于抗病毒的NK和T细胞免疫控制。通过这种方式，CX3CR1hi巡逻的单核细胞作为免疫特权载体，通过血流将MCMV运送到远端器官。MCMV侵占巡逻的单核细胞来介导系统感染，并为水平传播提供必要的持久储存库。
Peripheral blood myelomonocytic cells are important for cytomegalovirus dissemination to distal organs such as salivary glands where persistent replication and shedding dictates transmission patterns. We find that this process is markedly enhanced by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2, which promotes recruitment of CX3CR1hi patrolling monocytes to initial infection sites in the mouse. There, these cells become infected and traffic via the bloodstream to distal sites. In contrast, inflammatory monocytes, the other major myelomonocytic subset, remain virus negative. CX3CR1 deficiency prevents patrolling monocyte migration on the vascular endothelium and interrupts MCMV dissemination to the salivary glands independent of antiviral NK and T cell immune control. In this manner, CX3CR1hi patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the bloodstream to distal organs. MCMV commandeers patrolling monocytes to mediate systemic infection and seed a persistent reservoir essential for horizontal transmission.
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影响因子：
168.9
作者：
GILBERT, GL;HUDSON, IL;JAMES, J
通讯作者：
JAMES, J
影响因子：
5.3
作者：
Jung, S;Aliberti, J;Littman, DR
通讯作者：
Littman, DR
影响因子：
5.4
作者：
Avdic, Selmir;Cao, John Z.;Slobedman, Barry
通讯作者：
Slobedman, Barry
影响因子：
32.4
作者：
Cros J;Cagnard N;Woollard K;Patey N;Zhang SY;Senechal B;Puel A;Biswas SK;Moshous D;Picard C;Jais JP;D'Cruz D;Casanova JL;Trouillet C;Geissmann F
通讯作者：
Geissmann F
影响因子：
5.4
作者：
MANNING, WC;STODDART, CA;MOCARSKI, ES
通讯作者：
MOCARSKI, ES