Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats
Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats
复制标题
薰衣草油气味的嗅觉刺激影响大鼠的自主神经传递和血压
DOI：
10.1016/j.neulet.2005.12.076
复制
发表时间：
2006
影响因子：
2.5
通讯作者：
K. Nagai
中科院分区：
文献类型：
--
作者：
M. Tanida;A. Niijima;Jiao Shen;Takuo Nakamura;K. Nagai
以前，我们观察到，嗅觉刺激与熏衣草油的气味（SLVO）抑制交感神经活动和胃迷走神经（副交感神经）神经活动（GVNA）升高，降低血浆甘油浓度和体温，并提高大鼠的食欲。在这里，我们进一步表明，嗅觉刺激与SLVO降低肾交感神经活动（RSNA）和血压（BP）和升高GVNA在麻醉大鼠。用芳樟醇（熏衣草油的一种成分）进行嗅觉刺激，也会引起麻醉大鼠RSNA和BP的降低以及GVNA的增加。用硫酸锌预处理鼻腔引起的嗅觉缺失可消除SLVO和芳樟醇气味对RSNA、GVNA和BP的影响。此外，侧脑室注射硫代哌丁胺，组胺能H3-拮抗剂，取消了抑制RSNA和BP以及升高GVNA介导的SLVO和芳樟醇气味。最后，下丘脑视交叉上核（SCN）的双侧病变消除了RSNA和BP抑制以及由于SLVO或芳樟醇引起的GVNA升高。因此，可以得出结论，熏衣草油及其活性成分芳樟醇的气味通过中枢组胺能神经系统和SCN影响自主神经传递并降低血压。
Previously, we observed that olfactory stimulation with scent of lavender oil (SLVO) suppressed sympathetic nerve activities and elevated gastric vagal (parasympathetic) nerve activity (GVNA), decreased plasma glycerol concentration and body temperature, and enhanced appetite in rats. Here, we further showed that olfactory stimulation with SLVO lowered renal sympathetic nerve activity (RSNA) and blood pressure (BP) and elevated GVNA in urethane-anesthetized rats. Olfactory stimulation with linalool, a component of lavender oil, also elicited decreases in RSNA and BP and an increase in GVNA in urethane-anesthetized rats. Anosmia induced by pretreatment of the nasal cavity by application of ZnSO4eliminated the effects of both SLVO and scent of linalool on RSNA, GVNA and BP. Furthermore, intracerebroventricular administration of thioperamide, a histaminergic H3-antagonist, abolished the suppression of RSNA and BP as well as the elevation of GVNA mediated by both SLVO and scent of linalool. Finally, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) eliminated RSNA and BP suppression and the elevation of GVNA due to SLVO or linalool. Thus, it was concluded that scent of lavender oil and its active component, linalool, affects autonomic neurotransmission and reduces blood pressure through the central histaminergic nervous system and the SCN.
影响因子：
2.5
作者：
Tanida, M;Yamano, T;Nagai, K
通讯作者：
Nagai, K
DOI：
10.1016/0165-1838(92)90026-d
发表时间：
1992-09-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
NIIJIMA, A;NAGAI, K;NAKAGAWA, H
通讯作者：
NAKAGAWA, H