Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type.
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's prognosis varies depending on disease type.
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DOI：
10.1016/j.trsl.2020.10.011
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Huang RS
中科院分区：
文献类型：
--
作者：
Huang Y;Ling A;Pareek S;Huang RS
长链非编码rna （lncRNAs）的功能研究通常只在单一癌症类型的背景下进行。然而，lncRNA的组织特异性表达模式提出了一个问题，即在一种癌症类型中发现的lncRNA关联是否与其他癌症类型相关。在这里，我们研究了癌症基因组图谱（TCGA）中50种癌症相关lncrna的表达水平与24种癌症的生存数据之间的关系，目的是鉴定与预后相关的lncrna。我们的研究结果表明，在许多癌症中，某些lncrna的高表达水平始终与更差/更好的生存相关，而其他lncrna在不同类型的癌症中具有不同的预后作用。我们的分析还确定了20种以前未报道的新的未调整关联。此外，在低级别胶质瘤（LGG）中，在已知的临床生物标志物和常用治疗条件下，鉴定出与预后相关的lncrna，揭示了FOXP4-AS1和NEAT1 2个lncrna与替莫唑胺反应（LGG的标准治疗）相关。通路分析提示NEAT1高表达的LGG患者NF-kB/STAT3信号通路富集，FOXP4-AS1高表达的LGG患者DNA修复/myc基因集富集。我们的工作证明了lncrna在不同癌症类型中的环境依赖性，并强调了一些lncrna作为潜在的新型癌症预后标志物。
Functional studies of long noncoding RNAs (lncRNAs) are often performed in the context of only a single cancer type. However, the tissue-specific expression patterns of lncRNAs raise the question of whether lncRNA associations identified in one cancer type are relevant to other cancer types. Here, we examine the relationships between the expression levels of 50 cancer related lncRNAs and survival data from 24 types of cancer in The Cancer Genome Atlas (TCGA) with the goal of identifying prognosis related lncRNAs. Our results suggest that high expression levels of certain lncRNAs are consistently associated with worse/better survival in a number of cancers, while other lncRNAs have different prognostic roles in different types of cancer. Our analysis also identifies 20 novel unadjusted associations that have not been reported before. In addition, in low-grade glioma (LGG), prognostic related lncRNAs are identified after conditioning on known clinical biomarker and common therapy, revealing that 2 lncRNAs, FOXP4-AS1 and NEAT1, are associated with temozolomide response—a standard-of-care in LGG. Pathway analysis suggests NF-kB/STAT3 signaling pathway enrichment in LGG patients with high NEAT1 expression and DNA repair/myc gene set enrichment in LGG patients with high expression of FOXP4-AS1. Our work demonstrates the context dependency of lncRNAs across cancer types and highlights a number of lncRNAs as potential novel cancer prognosis markers.
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遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
影响因子：
3.8
作者：
Anaya, Jordan
通讯作者：
Anaya, Jordan
影响因子：
8.5
作者：
Li, Juan;Lian, Yifan;Wang, Keming
通讯作者：
Wang, Keming
影响因子：
9.7
作者：
Jia, Peng;Cai, Heng;Xue, Yixue
通讯作者：
Xue, Yixue
DOI：
10.3988/jcn.2019.15.1.1
发表时间：
2019-01
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Chammas M;Saadeh F;Maaliki M;Assi H
通讯作者：
Assi H