Genetics and geography of leukocyte telomere length in sub-Saharan Africans.
Genetics and geography of leukocyte telomere length in sub-Saharan Africans.
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DOI：
10.1093/hmg/ddaa187
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发表时间：
2020-11-04
影响因子：
3.5
通讯作者：
Tishkoff SA
中科院分区：
文献类型：
--
作者：
Hunt SC;Hansen MEB;Verhulst S;McQuillan MA;Beggs W;Lai TP;Mokone GG;Mpoloka SW;Meskel DW;Belay G;Nyambo TB;Abnet CC;Yeager M;Chanock SJ;Province MA;Williams SM;Aviv A;Tishkoff SA
白细胞端粒长度（LTL）可能是心血管疾病和主要癌症的原因。为了阐明遗传学和地理学在人类LTL变异中的作用，我们比较了1295名撒哈拉以南非洲人（SSA）与559名非洲裔美国人（AAms）和2464名欧洲裔美国人（EAms）的LTL。LTL在SSA之间差异显著（P = 0.003），来自博茨瓦纳的San（具有最古老的基因组祖先）具有最长的LTL，来自埃塞俄比亚的人群具有最短的LTL。SSA的LTL显著长于AAms [P = 6.5（e-16）]，AAms的LTL显著长于EAms [P = 2.5（e-7）]。SSA的遗传变异解释了52%的LTL方差，而AAms和EAms分别为27%和34%。遗传变异的调整消除了SSA之间的LTL差异。SSA之间的LTL遗传变异，与最长的LTL在San，支持这一假设，即较长的LTL是祖先在人类。确定驱动非洲LTL变异的因素可能对LTL相关疾病产生重要影响。
Leukocyte telomere length (LTL) might be causal in cardiovascular disease and major cancers. To elucidate the roles of genetics and geography in LTL variability across humans, we compared LTL measured in 1295 sub-Saharan Africans (SSAs) with 559 African–Americans (AAms) and 2464 European–Americans (EAms). LTL differed significantly across SSAs (P = 0.003), with the San from Botswana (with the oldest genomic ancestry) having the longest LTL and populations from Ethiopia having the shortest LTL. SSAs had significantly longer LTL than AAms [P = 6.5(e-16)] whose LTL was significantly longer than EAms [P = 2.5(e-7)]. Genetic variation in SSAs explained 52% of LTL variance versus 27% in AAms and 34% in EAms. Adjustment for genetic variation removed the LTL differences among SSAs. LTL genetic variation among SSAs, with the longest LTL in the San, supports the hypothesis that longer LTL was ancestral in humans. Identifying factors driving LTL variation in Africa may have important ramifications for LTL-associated diseases.
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影响因子：
20.1
作者：
Benetos A;Toupance S;Gautier S;Labat C;Kimura M;Rossi PM;Settembre N;Hubert J;Frimat L;Bertrand B;Boufi M;Flecher X;Sadoul N;Eschwege P;Kessler M;Tzanetakou IP;Doulamis IP;Konstantopoulos P;Tzani A;Korou M;Gkogkos A;Perreas K;Menenakos E;Samanidis G;Vasiloglou-Gkanis M;Kark JD;Malikov S;Verhulst S;Aviv A
通讯作者：
Aviv A
影响因子：
4.5
作者：
Stone RC;Horvath K;Kark JD;Susser E;Tishkoff SA;Aviv A
通讯作者：
Aviv A
影响因子：
7.8
作者：
Benetos A;Kark JD;Susser E;Kimura M;Sinnreich R;Chen W;Steenstrup T;Christensen K;Herbig U;von Bornemann Hjelmborg J;Srinivasan SR;Berenson GS;Labat C;Aviv A
通讯作者：
Aviv A
影响因子：
7.8
作者：
Kuo, Chia-Ling;Pilling, Luke C.;Melzer, David
通讯作者：
Melzer, David
影响因子：
2.9
作者：
Tackney, Justin;Cawthon, Richard M.;Coxworth, James E.;Hawkes, Kristen
通讯作者：
Hawkes, Kristen