Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19.
Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19.
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DOI：
10.1007/s12328-023-01755-4
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发表时间：
2023-04
影响因子：
1
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中科院分区：
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并发冠状病毒病2019(新冠肺炎)的肝功能障碍的发病机制尚不清楚，特别是在轻度到中度严重的病例中。在这种情况下，通过聚合酶链式反应(聚合酶链式反应)检测到一种新的冠状病毒感染，患者是一名76岁的妇女，在出现发烧后住院。没有观察到其他异常的体格检查结果，也不需要给氧。胸部CT显示右肺有磨玻璃样浸润性阴影，诊断为中度新冠肺炎。最初，发热消失，聚合酶链式反应转为阴性；然而，在住院第14天再次出现发热，CT显示肺炎加重并伴有新发的脂肪肝。生化检查显示明显的肝功能障碍，并伴有血清IL-6、IL-10和肿瘤坏死因子-α水平的升高。经保守治疗后，患者的体格检查和所有实验室指标均有所改善，于第22天出院。出院后44天进行的肝脏活检显示，以T细胞为主的炎症细胞浸润，主要在门脉区域。部分肝细胞出现脂肪变性。我们报告一例中度新冠肺炎的病例，在最初感染清除且相关转氨酶升高缓解后相当一段时间后，组织性肝炎仍持续存在，并与血清细胞因子动态进行比较。
The pathogenesis of liver dysfunction that complicates coronavirus disease 2019 (COVID-19) remains unclear, especially in mild to moderate severity cases. In this case, a novel coronavirus infection was detected by polymerase chain reaction (PCR) in a 76-year-old woman hospitalized after presenting with fever. No other abnormal physical findings were observed, and oxygen administration was not required. Chest computed tomography (CT) showed a ground-glass-like and an infiltrative shadow in the right lung, and moderate COVID-19 was diagnosed. Initially, the fever resolved, and PCR turned negative; however, the fever reappeared on hospitalization day 14, and CT showed pneumonia exacerbation accompanied by new onset of fatty liver. Biochemical testing revealed marked liver dysfunction, accompanied by elevated serum interleukin (IL)-6, IL-10, and tumor necrosis factor-α levels. Physical findings and all laboratory parameters improved after conservative treatment, and she was discharged on day 22. A liver biopsy performed 44 days post-discharge showed T-cell-dominant inflammatory cell infiltration, mainly in the portal region. Some hepatocytes showed fatty degeneration. We report a case of moderate COVID-19 in which histological hepatitis persisted after a substantial period had passed since the initial infection had cleared and associated transaminase elevations had resolved, with a comparison of serum cytokine dynamics.
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DOI：
10.5492/wjccm.v10.i3.47
发表时间：
2021-05-09
期刊：
World journal of critical care medicine
影响因子：
--
作者：
Tahtabasi M;Hosbul T;Karaman E;Akin Y;Kilicaslan N;Gezer M;Sahiner F
通讯作者：
Sahiner F
影响因子：
1.1
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影响因子：
6.3
作者：
Li D;Ding X;Xie M;Tian D;Xia L
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Xia L
影响因子：
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Sato, S;Kawashima, H;Hoshika, A
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影响因子：
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TORRE, D;ZEROLI, C;TAMBINI, R
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