COVID-19-associated liver injury: from bedside to bench.
COVID-19-associated liver injury: from bedside to bench.
复制标题
COVID-19 相关肝损伤：从床边到工作台
DOI：
10.1007/s00535-021-01760-9
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发表时间：
2021-03
影响因子：
6.3
通讯作者：
Xia L
中科院分区：
文献类型：
--
作者：
Li D;Ding X;Xie M;Tian D;Xia L
由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的2019年新冠肺炎疫情自2019年12月以来一直是一个全球性挑战。虽然大多数新冠肺炎患者的临床表现轻微，但在大约5%的患者中，疾病最终发展为严重的肺损伤，甚至多器官功能障碍。这种情况代表了肝病学面临的各种挑战。在新冠肺炎患者肝损伤的背景下，需要解决几个关键问题。例如，确定SARS-CoV-2是否可以直接侵入肝脏是很重要的，特别是当ACE2在肝细胞上的表达似乎可以忽略的时候。此外，新冠肺炎患者肝功能障碍的机制尚不完全清楚，可能是多因素的，与高炎症、免疫反应失调、凝血异常和药物有关。在这里，我们系统地描述了新冠肺炎相关性肝损伤的潜在发病机制，并提出了几种关于其发病机制的假说。
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a global challenge since December 2019. Although most patients with COVID-19 exhibit mild clinical manifestations, in approximately 5% of these patients, the disease eventually progresses to severe lung injury or even multiorgan dysfunction. This situation represents various challenges to hepatology. In the context of liver injury in patients with COVID-19, several key problems need to be solved. For instance, it is important to determine whether SARS-CoV-2 can directly invade liver, especially when ACE2 appears to be negligibly expressed on hepatocytes. In addition, the mechanisms underlying liver dysfunction in COVID-19 patients are not fully understood, which are likely multifactorial and related to hyperinflammation, dysregulated immune responses, abnormal coagulation and drugs. Here, we systematically describe the potential pathogenesis of COVID-19-associated liver injury and propose several hypotheses about its etiopathogenesis.
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影响因子：
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