Genome-wide association study identifies eight loci associated with blood pressure.
Genome-wide association study identifies eight loci associated with blood pressure.
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DOI：
10.1038/ng.361
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发表时间：
2009-06
期刊：
影响因子：
30.8
通讯作者：
Munroe, Patricia B.
中科院分区：
文献类型：
--
作者：
Newton-Cheh, Christopher;Johnson, Toby;Gateva, Vesela;Tobin, Martin D.;Bochud, Murielle;Coin, Lachlan;Najjar, Samer S.;Zhao, Jing Hua;Heath, Simon C.;Eyheramendy, Susana;Papadakis, Konstantinos;Voight, Benjamin F.;Scott, Laura J.;Zhang, Feng;Farrall, Martin;Tanaka, Toshiko;Wallace, Chris;Chambers, John C.;Khaw, Kay-Tee;Nilsson, Peter;van der Harst, Pim;Polidoro, Silvia;Grobbee, Diederick E.;Onland-Moret, N. Charlotte;Bots, Michiel L.;Wain, Louise V.;Elliott, Katherine S.;Teumer, Alexander;Luan, Jian'an;Lucas, Gavin;Kuusisto, Johanna;Burton, Paul R.;Hadley, David;McArdle, Wendy L.;Brown, Morris;Dominiczak, Anna;Newhouse, Stephen J.;Samani, Nilesh J.;Webster, John;Zeggini, Eleftheria;Beckmann, Jacques S.;Bergmann, Sven;Lim, Noha;Song, Kijoung;Vollenweider, Peter;Waeber, Gerard;Waterworth, Dawn M.;Yuan, Xin;Groop, Leif;Orho-Melander, Marju;Allione, Alessandra;Di Gregorio, Alessandra;Guarrera, Simonetta;Panico, Salvatore;Ricceri, Fulvio;Romanazzi, Valeria;Sacerdote, Carlotta;Vineis, Paolo;Barroso, Ines;Sandhu, Manjinder S.;Luben, Robert N.;Crawford, Gabriel J.;Jousilahti, Pekka;Perola, Markus;Boehnke, Michael;Bonnycastle, Lori L.;Collins, Francis S.;Jackson, Anne U.;Mohlke, Karen L.;Stringham, Heather M.;Valle, Timo T.;Willer, Cristen J.;Bergman, Richard N.;Morken, Mario A.;Doering, Angela;Gieger, Christian;Illig, Thomas;Meitinger, Thomas;Org, Elin;Pfeufer, Arne;Wichmann, H. Erich;Kathiresan, Sekar;Marrugat, Jaume;O'Donnell, Christopher J.;Schwartz, Stephen M.;Siscovick, David S.;Subirana, Isaac;Freimer, Nelson B.;Hartikainen, Anna-Liisa;McCarthy, Mark I.;O'Reilly, Paul F.;Peltonen, Leena;Pouta, Anneli;de Jong, Paul E.;Snieder, Harold;van Gilst, Wiek H.;Clarke, Robert;Goel, Anuj;Hamsten, Anders;Peden, John F.;Seedorf, Udo;Syvanen, Ann-Christine;Tognoni, Giovanni;Lakatta, Edward G.;Sanna, Serena;Scheet, Paul;Schlessinger, David;Scuteri, Angelo;Doerr, Marcus;Ernst, Florian;Felix, Stephan B.;Homuth, Georg;Lorbeer, Roberto;Reffelmann, Thorsten;Rettig, Rainer;Voelker, Uwe;Galan, Pilar;Gut, Ivo G.;Hercberg, Serge;Lathrop, G. Mark;Zelenika, Diana;Deloukas, Panos;Soranzo, Nicole;Williams, Frances M.;Zhai, Guangju;Salomaa, Veikko;Laakso, Markku;Elosua, Roberto;Forouhi, Nita G.;Volzke, Henry;Uiterwaal, Cuno S.;van der Schouw, Yvonne T.;Numans, Mattijs E.;Matullo, Giuseppe;Navis, Gerjan;Berglund, Goran;Bingham, Sheila A.;Kooner, Jaspal S.;Connell, John M.;Bandinelli, Stefania;Ferrucci, Luigi;Watkins, Hugh;Spector, Tim D.;Tuomilehto, Jaakko;Altshuler, David;Strachan, David P.;Laan, Maris;Meneton, Pierre;Wareham, Nicholas J.;Uda, Manuela;Jarvelin, Marjo-Riitta;Mooser, Vincent;Melander, Olle;Loos, Ruth J. F.;Elliott, Paul;Abecasis, Goncalo R.;Caulfield, Mark;Munroe, Patricia B.
高血压是世界范围内心血管疾病的一种常见的可遗传原因。到目前为止，识别影响血压的常见基因变异是具有挑战性的。我们对来自全球BP基因联盟的34,433名欧洲血统的受试者进行了250万个基因分型和归因于与收缩和舒张压相关的SNPs测试，并通过直接基因分型(N≤71,225个欧洲血统，N=12,889个印度亚洲血统)和电子比较(Charge联盟，N=29,136)进行了后续研究。我们发现收缩压或舒张压与8个常见的变异相关，分别位于细胞色素P17A1(P=7×10−24)、细胞色素P1A2(P=1×10−23)、FGF5(P=1×10−21)、SH2B3(P=3×10−18)、MTHFR(P=2×10−13)、C10orf107(P=1×10−9)、ZNF652(P=5×10−9)和PLCD3(P=1×10−8)基因附近。所有与持续血压相关的变异都与二分性高血压有关。这些常见的变异与血压和高血压之间的联系为血压的调节提供了机械性的见解，并可能指出预防心血管疾病的干预措施的新靶点。
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5m genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N≤71,225 European ancestry, N=12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N=29,136). We identified association between systolic or diastolic blood pressure and common variants in 8 regions near the CYP17A1 (P=7×10−24), CYP1A2 (P=1×10−23), FGF5 (P=1×10−21), SH2B3 (P=3×10−18), MTHFR (P=2×10−13), c10orf107 (P=1×10−9), ZNF652 (P=5×10−9) and PLCD3 (P=1×10−8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
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影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
影响因子：
5
作者：
DYER, AR;SHIPLEY, M;ELLIOTT, P
通讯作者：
ELLIOTT, P
影响因子：
30.8
作者：
Gudbjartsson, Daniel F.;Bjornsdottir, Unnur S.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
30.8
作者：
Levy, Daniel;Ehret, Georg B.;Rice, Kenneth;Verwoert, Germaine C.;Launer, Lenore J.;Dehghan, Abbas;Glazer, Nicole L.;Morrison, Alanna C.;Johnson, Andrew D.;Aspelund, Thor;Aulchenko, Yurii;Lumley, Thomas;Koettgen, Anna;Vasan, Ramachandran S.;Rivadeneira, Fernando;Eiriksdottir, Gudny;Guo, Xiuqing;Arking, Dan E.;Mitchell, Gary F.;Mattace-Raso, Francesco U. S.;Smith, Albert V.;Taylor, Kent;Scharpf, Robert B.;Hwang, Shih-Jen;Sijbrands, Eric J. G.;Bis, Joshua;Harris, Tamara B.;Ganesh, Santhi K.;O'Donnell, Christopher J.;Hofman, Albert;Rotter, Jerome I.;Coresh, Josef;Benjamin, Emelia J.;Uitterlinden, Andre G.;Heiss, Gerardo;Fox, Caroline S.;Witteman, Jacqueline C. M.;Boerwinkle, Eric;Wang, Thomas J.;Gudnason, Vilmundur;Larson, Martin G.;Chakravarti, Aravinda;Psaty, Bruce M.;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.