Intrauterine exposure to fine particulate matter as a risk factor for increased susceptibility to acute broncho-pulmonary infections in early childhood.
Intrauterine exposure to fine particulate matter as a risk factor for increased susceptibility to acute broncho-pulmonary infections in early childhood.
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DOI：
10.1016/j.ijheh.2012.12.014
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发表时间：
2013-07
影响因子：
6
通讯作者：
Jacek, Ryszard
中科院分区：
文献类型：
--
作者：
Jedrychowski, Wieslaw A.;Perera, Frederica P.;Spengler, John D.;Mroz, Elzbieta;Stigter, Laura;Flak, Elzbieta;Majewska, Renata;Klimaszewska-Rembiasz, Maria;Jacek, Ryszard
在过去的几十年中，许多流行病学研究考虑了通常在产后测量的环境空气污染背景下儿童呼吸系统疾病和肺功能的发病模式。本研究的主要目的是评估产前接触细颗粒物（PM2.5）对儿童早期反复支气管肺部感染的影响。该研究纳入了 214 名儿童，他们测量了个人产前 PM2.5 暴露量，并在七年的随访中定期收集医生诊断出的急性支气管炎和肺炎发生率的数据。产前暴露于 PM2.5 的影响在多变量逻辑模型中针对潜在混杂因素进行了调整，例如产前和产后 ETS（环境烟草烟雾）、城市居住区作为产后城市暴露的代理、儿童对国内空气过敏原的敏感性和哮喘。在现有 PM2.5 室内水平的儿童亚组中，产前暴露的影响也针对室内暴露进行了额外调整。随访中记录的复发性支气管肺部感染（五次或以上支气管炎和/或肺炎）发生率的调整比值比（OR）与产前 PM2.5 水平以剂量反应方式显着相关（OR = 2.44，95%CI：1.12 – 5.36）。总之，该研究表明，产前接触 PM2.5 会增加对呼吸道感染的易感性，并可能会影响儿童早期的呼吸道疾病发病率。该研究还提供证据表明，24 小时 PM2.5 平均水平的目标值 20 μg/m3 比早期制定的 EPA 指南更能保护未出生的婴儿。
Over the last decades many epidemiologic studies considered the morbidity patterns for respiratory diseases and lung function of children in the context of ambient air pollution usually measured in the postnatal period. The main purpose of this study is to assess the impact of prenatal exposure to fine particulate matter (PM2.5) on the recurrent broncho-pulmonary infections in early childhood. The study included 214 children who had measurements of personal prenatal PM2.5 exposure and regularly collected data on the occurrence of acute bronchitis and pneumonia diagnosed by a physician from birth over the seven-year follow-up. The effect of prenatal exposure to PM2.5 was adjusted in the multivariable logistic models for potential confounders, such as prenatal and postnatal ETS (environmental tobacco smoke), city residence area as a proxy of postnatal urban exposure, children’s sensitization to domestic aeroallergens, and asthma. In the subgroup of children with available PM2.5 indoor levels, the effect of prenatal exposure was additionally adjusted for indoor exposure as well. The adjusted odds ratio (OR) for incidence of recurrent broncho-pulmonary infections (five or more spells of bronchitis and/or pneumonia) recorded in the follow-up significantly correlated in a dose-response manner with the prenatal PM2.5 level (OR = 2.44, 95%CI: 1.12 – 5.36). In conclusion, the study suggests that prenatal exposure to PM2.5 increases susceptibility to respiratory infections and may program respiratory morbidity in early childhood. The study also provides evidence that the target value of 20 μg/m3 for the 24-hour mean level of PM2.5 protects unborn babies better than earlier established EPA guidelines.
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DOI：
10.1165/rcmb.2002-0115oc
发表时间：
2003-06-01
影响因子：
6.4
作者：
Kaan, PM;Hegele, RG
通讯作者：
Hegele, RG
DOI：
10.1016/s0162-3109(00)00234-4
发表时间：
2000-07-25
期刊：
IMMUNOPHARMACOLOGY
影响因子：
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作者：
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通讯作者：
Diaz-Sanchez, D
影响因子：
5.4
作者：
Schwartz, J;Neas, LM
通讯作者：
Neas, LM
DOI：
10.1164/rccm.200411-1586oc
发表时间：
2005-06-01
影响因子：
24.7
作者：
Barnett, AG;Williams, GM;Simpson, RW
通讯作者：
Simpson, RW
影响因子：
4.4
作者：
Laupeze, W;Amiot, L;Fardel, O
通讯作者：
Fardel, O