An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic.
An open source heterogeneous 3D printed mouse phantom utilising a novel bone representative thermoplastic.
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DOI：
10.1088/1361-6560/ab8078
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发表时间：
2020-06-03
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
临床前辐射剂量测定缺乏严格的质量标准，重新引起了人们对拟人幻影发展的兴趣。使用3D打印可以创建可定制的幻影，以评估临床前放射研究的所有部分：规划，图像引导和治疗实施。我们提出了完整的方法，包括材料开发和印刷设计，生产高空间分辨率，解剖学上逼真的异质小动物模型。介绍了一种用于创建和验证组织等效材料的方法。该技术通过开发骨等效材料进行了证明。该材料与软组织模仿ABS塑料细丝一起使用，以再现从裸鼠CT扫描中捕获的相应结构几何形状。空气间隙用于表示肺。通过比较体模和动物图像的CT图像的几何形状和X射线衰减进行体模确认。在较软的光束（0.5 mm Cu HVL）中，骨等同材料与参考标准相比的衰减差异为6.6%，随着光束硬化，衰减迅速减小。CT成像显示骨骼（一致性距离0.5 mm ± 0.4 mm）和体表（0.7 mm ± 0.5 mm）的精确（亚毫米）再现。体模的体素强度轮廓的直方图证明与原始小鼠图像和不同动物的体素强度轮廓的直方图具有适当的相似性。我们提出了一种方法，用于有效地生产一个拟人化的幻影适合于临床前放射治疗的质量保证。我们的设计和完整的方法作为开源提供，以鼓励临床前放射生物学社区采用通用的QA标准。 缩写ABS -丙烯腈丁二烯苯乙烯，CBCT -锥形束计算机断层扫描，FDM -熔融沉积建模，HVL -半值层，HU -亨氏单位，ICRU -国际辐射单位和测量委员会，NIST -国家标准与技术研究所，NPL -国家物理实验室，QA -质量保证，ROI -感兴趣区域，SARRP -小动物辐射研究平台，STL -立体光刻。
The lack of rigorous quality standards in pre-clinical radiation dosimetry has renewed interest in the development of anthropomorphic phantoms. Using 3D printing customisable phantoms can be created to assess all parts of pre-clinical radiation research: planning, image guidance and treatment delivery. We present the full methodology, including material development and printing designs, for the production of a high spatial resolution, anatomically realistic heterogeneous small animal phantom. A methodology for creating and validating tissue equivalent materials is presented. The technique is demonstrated through the development of a bone-equivalent material. This material is used together with a soft-tissue mimicking ABS plastic filament to reproduce the corresponding structure geometries captured from a CT scan of a nude mouse. Air gaps are used to represent the lungs. Phantom validation was performed through comparison of the geometry and x-ray attenuation of CT images of the phantom and animal images. A 6.6% difference in the attenuation of the bone-equivalent material compared to the reference standard in softer beams (0.5 mm Cu HVL) rapidly decreases as the beam is hardened. CT imaging shows accurate (sub-millimetre) reproduction of the skeleton (Distance-To-Agreement 0.5 mm ± 0.4 mm) and body surface (0.7 mm ± 0.5 mm). Histograms of the voxel intensity profile of the phantom demonstrate suitable similarity to those of both the original mouse image and that of a different animal. We present an approach for the efficient production of an anthropomorphic phantom suitable for the quality assurance of pre-clinical radiotherapy. Our design and full methodology are provided as open source to encourage the pre-clinical radiobiology community to adopt a common QA standard. Abbreviations ABS – acrylonitrile butadiene styrene, CBCT – cone beam computed tomography, FDM – fused deposition modelling, HVL – half value layer, HU – Hounsfield units, ICRU - International Commission on Radiation Units and Measurements, NIST – National Institute of Standards and Technology, NPL – National Physical Laboratory, QA – quality assurance, ROI – region of interest, SARRP – small animal radiation research platform, STL – stereolithography.
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影响因子：
2.1
作者：
Kumar, Rajesh;Sharma, S. D.;Mayya, Y. S.
通讯作者：
Mayya, Y. S.
DOI：
10.1016/j.nimb.2008.06.034
发表时间：
2008-09-01
影响因子：
1.3
作者：
Manohara, S. R.;Hanagodimath, S. M.;Gerward, L.
通讯作者：
Gerward, L.
DOI：
10.1016/s0360-3016(02)02884-5
发表时间：
2002-08-01
影响因子：
7
作者：
Jaffray, DA;Siewerdsen, JH;Martinez, AA
通讯作者：
Martinez, AA
DOI：
10.6028/jres.118.021
发表时间：
2013
影响因子：
1.5
作者：
Desrosiers M;DeWerd L;Deye J;Lindsay P;Murphy MK;Mitch M;Macchiarini F;Stojadinovic S;Stone H
通讯作者：
Stone H
DOI：
10.1016/j.jmatprotec.2012.12.015
发表时间：
2013-06-01
影响因子：
6.3
作者：
McCullough, Eric J.;Yadavalli, Vamsi K.
通讯作者：
Yadavalli, Vamsi K.