The Importance of Dosimetry Standardization in Radiobiology.
The Importance of Dosimetry Standardization in Radiobiology.
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DOI：
10.6028/jres.118.021
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发表时间：
2013
影响因子：
1.5
通讯作者：
Stone H
中科院分区：
文献类型：
--
作者：
Desrosiers M;DeWerd L;Deye J;Lindsay P;Murphy MK;Mitch M;Macchiarini F;Stojadinovic S;Stone H
辐射剂量是许多放射生物学研究的中心问题。剂量测量的精度和准确性以及测量细节的报告应足以使工作能够解释和重复，并允许在同一实验室和其他实验室进行有效的比较。尽管如此，仔细阅读已发表的手稿表明，辐射剂量学的测量和报告以及放射生物学研究的设置往往不足，从而破坏了研究结果的可靠性和可重复性。为了解决这些问题并提出行动方案，2011年9月，美国国家癌症研究所（NCI）、美国国家过敏和传染病研究所（NIAID）和美国国家标准与技术研究所（NIST）召集了放射生物学和辐射物理学界的代表参加了一次研讨会。研讨会参与者达成了一些具体的建议，如本文所列举的，他们表达了为细胞培养和小型和大型动物实验创建剂量学标准操作程序（sop）的愿望。还有人认为，如果通过诸如网络等机制广泛提供这些标准操作程序，将是最有用的，因为这些标准操作程序可以为放射生物学家和放射物理学家提供指导，在出版物中被引用，并随着领域和需求的发展而更新。所涉及的其他广泛领域包括需要通过在国家会议上的辅导进行继续教育，以及需要期刊建立报告剂量学的标准。这次讲习班没有讨论涉及亚细胞水平辐射研究的剂量学、内部给药放射性核素、基于辐射照射生物标记物的生物剂量学或流行病学研究的剂量重建等问题。
Radiation dose is central to much of radiobiological research. Precision and accuracy of dose measurements and reporting of the measurement details should be sufficient to allow the work to be interpreted and repeated and to allow valid comparisons to be made, both in the same laboratory and by other laboratories. Despite this, a careful reading of published manuscripts suggests that measurement and reporting of radiation dosimetry and setup for radiobiology research is frequently inadequate, thus undermining the reliability and reproducibility of the findings. To address these problems and propose a course of action, the National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), and the National Institute of Standards and Technology (NIST) brought together representatives of the radiobiology and radiation physics communities in a workshop in September, 2011. The workshop participants arrived at a number of specific recommendations as enumerated in this paper and they expressed the desirability of creating dosimetry standard operating procedures (SOPs) for cell culture and for small and large animal experiments. It was also felt that these SOPs would be most useful if they are made widely available through mechanism(s) such as the web, where they can provide guidance to both radiobiologists and radiation physicists, be cited in publications, and be updated as the field and needs evolve. Other broad areas covered were the need for continuing education through tutorials at national conferences, and for journals to establish standards for reporting dosimetry. This workshop did not address issues of dosimetry for studies involving radiation focused at the sub-cellular level, internally-administered radionuclides, biodosimetry based on biological markers of radiation exposure, or dose reconstruction for epidemiological studies.
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