Behavioral mediators of stress-related mood symptoms in adolescence & young adulthood.
Behavioral mediators of stress-related mood symptoms in adolescence & young adulthood.
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DOI：
10.1016/j.jad.2021.06.079
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发表时间：
2021-11-01
影响因子：
6.6
通讯作者：
Kaiser RH
中科院分区：
文献类型：
--
作者：
Peterson EC;Rosenberg BM;Hough CM;Sandman CF;Neilson C;Miklowitz DJ;Kaiser RH
压力是单极性和双极性情绪障碍的危险因素，但将压力与特定症状联系起来的机制仍然难以捉摸。对压力的行为反应，如冲动和社交退缩，可能介导压力和特定情绪症状之间的关联。这项研究评估了长达八周的日常日记调查自我报告的日常压力强度和情绪症状之间的关系的行为介质。样本包括患有单相或双相情感障碍或无精神病史的个体（n = 113，年龄15-25）。结果表明，较高的日常压力与较高的躁狂症的严重程度，这一途径是由冲动行为介导的。更高的压力也预示着更高的严重程度的快感缺失型抑郁症，和社会退缩介导的这种关系。K-均值聚类分析显示，6个亚组与不同的配置文件的压力行为症状的途径。鉴于观察性研究设计，分析无法确定这些变量之间的因果关系。需要进一步的工作，以确定这些变量之间的关系可能会有所不同的压力源类型的基础上，在不同的时间尺度，在不同的人群。研究结果支持了一个理论模型，其中冲动和社会退缩行为的压力和情绪症状之间的关系的调解人。此外，不同的反应模式区分了易受特定类型情绪症状影响的人群。这些结果提供了新的信息，压力反应行为与特定的情绪症状，这可能有临床相关性的干预目标。
Stress is a risk factor for unipolar and bipolar mood disorders, but the mechanisms linking stress to specific symptoms remain elusive. Behavioral responses to stress, such as impulsivity and social withdrawal, may mediate the associations between stress and particular mood symptoms. This study evaluated behavioral mediators of the relationship between self-reported intensity of daily stress and mood symptoms over up to eight weeks of daily diary surveys. The sample included individuals with unipolar or bipolar disorders, or with no psychiatric history (n = 113, ages 15–25). Results showed that higher daily stress was related to higher severity of mania, and this pathway was mediated by impulsive behaviors. Higher stress also predicted higher severity of anhedonic depression, and social withdrawal mediated this relationship. A k-means clustering analysis revealed six subgroups with divergent profiles of stress-behavior-symptom pathways. Given the observational study design, analyses cannot determine causal relationships amongst these variables. Further work is needed to determine how relationships between these variables may vary based on stressor type, at different timescales, and within different populations. Findings support a theoretical model in which impulsivity and social withdrawal act as behavioral mediators of the relationship between stress and mood symptoms. Additionally, distinct patterns of reactivity distinguished subgroups of people vulnerable to particular types of mood symptoms. These results provide novel information about how stress-reactive behaviors relate to specific mood symptoms, which may have clinical relevance as targets of intervention.
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影响因子：
3.8
作者：
Auerbach RP;Admon R;Pizzagalli DA
通讯作者：
Pizzagalli DA
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
11
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
通讯作者：
Martin NG
DOI：
10.1176/appi.ajp.2010.09071011
发表时间：
2010-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Angst J;Cui L;Swendsen J;Rothen S;Cravchik A;Kessler RC;Merikangas KR
通讯作者：
Merikangas KR
影响因子：
6.6
作者：
Belzeaux, Raoul;Boyer, Laurent;Azorin, Jean-Michel
通讯作者：
Azorin, Jean-Michel