Female alternative mating tactics, reproductive success and nonapeptide receptor expression in the social decision-making network.
Female alternative mating tactics, reproductive success and nonapeptide receptor expression in the social decision-making network.
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DOI：
10.1016/j.bbr.2013.02.024
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发表时间：
2013-06-01
影响因子：
2.7
通讯作者：
Ophir, Alexander G.
中科院分区：
文献类型：
--
作者：
Zheng, Da-Jiang;Larsson, Britta;Phelps, Steven M.;Ophir, Alexander G.
交配的决定可能是动物做出的最重要的决定之一。对于一夫一妻制的物种来说，这一决定可能会限制未来的交配机会。管理这些决策的机制可能是由进化以优化决策过程的方式塑造的。特别地，已经提出了所谓的社会决策网络（SDM），其将包括“社会行为网络”的大脑结构与与奖励相关联的神经系统相集成。在这里，我们调查的SDM催产素和加压素受体（OTR，V1aR）的女性社会一夫一妻制草原田鼠生活在自然条件下的神经表型差异。我们关注这些受体是因为它们与哺乳动物的社会行为密切相关。我们发现，V1aR的终纹，内侧杏仁核和腹侧苍白球的床核，和OTR的脑桥核和海马之间的怀孕和非怀孕的女性显着不同。其中大多数领域与可持续发展机制的奖励部分关系更为密切。V1aR在腹侧苍白球也大于配对比单身女性。最后，交配策略内的生殖成功与整个SDM的大脑结构中的受体密度有关，特别是那些作为社会行为网络和奖励系统之间的界面的受体密度。我们的数据支持这一假设，神经表型的神经调节九肽受体内的SDM涉及与生殖决策的自然行为。
The decision to mate may be one of the most important decisions that animals make. For monogamous species, this decision can carry the added weight of limiting future mating opportunities. The mechanisms that govern these decisions have presumably been shaped by evolution in ways that optimize decision-making processes. In particular, a so-called social decision-making network (SDM) has been proposed, which integrates brain structures comprising the ‘social behavior network’ with a neural system associated with reward. Here, we investigate the neural phenotypic differences in the SDM for oxytocin and vasopressin receptors (OTR, V1aR) of female socially monogamous prairie voles living in naturalistic conditions. We focus on these receptors because they are profoundly involved in mammalian social behavior. We found that V1aR in the bed nucleus of the stria terminalis, medial amygdala and ventral pallidum, and OTR in the nucleus accumbens and hippocampus significantly differed between pregnant and non-pregnant females. Most of these areas are more closely related to the reward component of the SDM. V1aR in the ventral pallidum was also greater in paired than in single females. Finally, reproductive success within mating tactics was related to receptor density in brain structures across the SDM, particularly those serving as the interface between the social behavior network and the reward system. Our data support the hypothesis that neural phenotype for neuromodulatory nonapeptide receptors within the SDM relates to natural behavior associated with reproductive decisions.
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影响因子：
8.2
作者：
Ikemoto, Satoshi
通讯作者：
Ikemoto, Satoshi
影响因子：
56.9
作者：
DLUZEN, DE;RAMIREZ, VD;GETZ, LL
通讯作者：
GETZ, LL
影响因子：
3.3
作者：
INSEL, TR;GELHARD, R;SHAPIRO, LE
通讯作者：
SHAPIRO, LE
影响因子：
2.5
作者：
GUILFORD, T;DAWKINS, MS
通讯作者：
DAWKINS, MS
影响因子：
56.9
作者：
EMLEN, ST;ORING, LW
通讯作者：
ORING, LW