Outcome of Targeted Therapy Recommendations for Metastatic and Recurrent Head and Neck Cancers.
Outcome of Targeted Therapy Recommendations for Metastatic and Recurrent Head and Neck Cancers.
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转移性和复发性头颈癌的靶向治疗建议的结果。
DOI：
10.3390/cancers12113381
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发表时间：
2020-11-15
期刊：
影响因子：
5.2
通讯作者：
Prager GW
中科院分区：
文献类型：
--
作者：
Taghizadeh H;Mader RM;Müllauer L;Fuereder T;Kautzky-Willer A;Prager GW
在这项回顾性研究中，我们旨在根据各自的个体分子谱为复发/转移性头颈癌患者提供分子驱动的治疗建议。50例患者中有31例（占所有患者的62.0%）可推荐靶向治疗方法。男性的治疗建议明显多于女性。最终，14名患者（28%）接受了推荐的靶向治疗。6例患者（12%）病情稳定，4例患者（8%）病情进展。治疗失败的中位时间为2.8个月。我们的分析表明，尽管精准医学方法在日常临床常规中用于治疗复发/转移性头颈癌是可行的，但仍有一些主要的限制和挑战需要克服。复发/转移（R/M）头颈癌预后不良。在本分析中，我们检查了在所有标准治疗方案失败后，基于患者分子肿瘤画像的靶向治疗建议的疗效和结果。在我们精准医疗平台的单中心、真实世界回顾性分析中，我们分析了50名诊断为R/M头颈癌的患者的分子谱。采用突变热点测序、微卫星不稳定性（MSI）检测和免疫组化（IHC）检测患者肿瘤样本。在31例（占所有患者的62.0%）中，推荐了分子驱动的靶向治疗方法。最终，14名患者（28%）接受了建议的靶向治疗。14例患者中有6例（43%）病情稳定，4例（29%）病情进展。治疗失败的中位时间为2.8个月。男性的治疗建议明显多于女性（p = 0.037）。该分析表明，精准医学为超过一半的晚期难治性头颈癌患者提供了分子驱动治疗建议的基础，其中男性治疗建议明显更多。我们的分析表明，尽管精准医学方法在日常临床常规中用于治疗复发/转移性头颈癌是可行的，但仍有一些主要的限制和挑战需要克服。
In this retrospective study, we aimed to provide molecular-driven therapy recommendations for patients with recurrent/metastatic head and neck cancers based on the respective individual molecular profile. For 31 of 50 patients (62.0% of all patients), a targeted therapy approach could be recommended. Therapy recommendations were significantly more often issued for men than for women. Eventually, 14 patients (28%) received the recommended targeted therapy. Six patients (12%) achieved stable disease and four patients (8%) experienced progressive disease. The median time to treatment failure was 2.8 months. Our analysis showed that although precision medicine approaches are implementable and feasible for the management of recurrent/metastatic head and neck cancers in daily clinical routine, there are major limitations and challenges that have to be overcome. Recurrent/metastatic (R/M) head and neck cancers bear a poor prognosis. In this analysis, we examined the efficacy and the outcome of targeted therapy recommendations based on the patients’ molecular tumor portrait after failure of all standard therapy options. In this single-center, real-world retrospective analysis of our platform for precision medicine, we analyzed the molecular profile of 50 patients diagnosed with R/M head and neck cancer. Tumor samples of the patients were examined using next-generation sequencing panels of mutation hotspots, microsatellite instability (MSI) testing, and immunohistochemistry (IHC). In 31 cases (62.0% of all patients), a molecular-driven targeted therapy approach was recommended. Eventually, 14 patients (28%) received the suggested targeted therapy. Six of fourteen patients (43%) achieved stable disease conditions and four patients (29%) experienced a progressive disease. The median time to treatment failure was 2.8 months. Therapy recommendations were significantly more often issued for men (p = 0.037) than for women. This analysis demonstrated that precision medicine provided the basis for molecular-driven therapy recommendations in over half of the patients with advanced therapy refractory head and neck cancers, with significantly more therapy recommendations for men. Our analysis showed that although precision medicine approaches are implementable and feasible for the management of recurrent/metastatic head and neck cancers in daily clinical routine, there are major limitations and challenges that have to be overcome.
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影响因子：
45.3
作者：
Blanke, Charles D.;Rankin, Cathryn;Borden, Ernest C.
通讯作者：
Borden, Ernest C.
DOI：
10.1016/j.coms.2018.09.003
发表时间：
2019-02-01
影响因子：
1.5
作者：
Sindhu, Simran K.;Bauman, Julie E.
通讯作者：
Bauman, Julie E.
影响因子：
3.3
作者：
Jiang, Xiaohua;Ye, Jing;Xiao, Mang
通讯作者：
Xiao, Mang
影响因子：
6
作者：
Zhang, Pan;Mirani, Neena;Fernandes, Helen
通讯作者：
Fernandes, Helen
DOI：
10.1158/1078-0432.ccr-13-1836
发表时间：
2014-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Koeppen H;Yu W;Zha J;Pandita A;Penuel E;Rangell L;Raja R;Mohan S;Patel R;Desai R;Fu L;Do A;Parab V;Xia X;Januario T;Louie SG;Filvaroff E;Shames DS;Wistuba I;Lipkind M;Huang J;Lazarov M;Ramakrishnan V;Amler L;Phan SC;Patel P;Peterson A;Yauch RL
通讯作者：
Yauch RL