Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: Associations with race, depressive symptoms, and low birth weight.
Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: Associations with race, depressive symptoms, and low birth weight.
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DOI：
10.1016/j.psyneuen.2016.08.025
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发表时间：
2016-12
影响因子：
3.7
通讯作者：
Palettas M
中科院分区：
文献类型：
--
作者：
Christian LM;Mitchell AM;Gillespie SL;Palettas M
脑源性神经营养因子（BDNF）被认为是重度抑郁症的一个致病因素，对妊娠期间的胎盘发育至关重要。在围产期BDNF的纵向数据缺乏。考虑到对母亲情绪和胎儿生长的潜在影响，这些数据是令人感兴趣的，特别是在黑人妇女中，她们分娩低出生体重儿的风险高出2倍。在139名妇女（77名黑人，62名白色）中，在每个妊娠期和产后4-11周评估血清BDNF、血清皮质醇和抑郁症状（根据CES-D）。通过病历确定低出生体重（<2500 g）。血清BDNF在妊娠早期至妊娠晚期显著下降（p ≤ 0.008），随后在产后升高（p < 0.001）。黑人妇女在妊娠早期、妊娠中期和产后（ps ≤ 0.032）血清BDNF显著较高，而在妊娠中期和妊娠晚期血清皮质醇较低（ps ≤ 0.01）。高血清皮质醇与低血清BDNF仅在孕中期相关（p < 0.05）。在控制种族因素后，孕2、3个月血清BDNF水平与孕3个月抑郁症状呈负相关（ps ≤ 0.02）。此外，分娩低体重儿的妇女与分娩健康体重儿的妇女相比，在妊娠晚期血清BDNF水平显著降低（p = 0.004）。分娩低体重儿与健康体重儿的妇女在妊娠期间任何时间点的抑郁症状均无差异（ps ≥ 0.34）。血清BDNF在黑人和白色妇女怀孕期间显著下降，黑人总体水平较高。在黑人和白色妇女中，妊娠晚期较低的血清BDNF与较高的抑郁症状和低出生体重的风险相对应。然而，妊娠期血清BDNF的预测价值是特定的种族内比较。血清BDNF的种族差异和差异妊娠相关的皮质醇适应之间的潜在联系需要进一步调查。
Brain-derived neurotrophic factor (BDNF) is implicated as a causal factor in major depression and is critical to placental development during pregnancy. Longitudinal data on BDNF across the perinatal period are lacking. These data are of interest given the potential implications for maternal mood and fetal growth, particularly among Black women who show ~2-fold greater risk for delivering low birth weight infants. Serum BDNF, serum cortisol, and depressive symptoms (per CES-D) were assessed during each trimester and 4–11 weeks postpartum among 139 women (77 Black, 62 White). Low birth weight (<2500 g) was determined via medical record. Serum BDNF declined considerably from 1st through 3rd trimesters (ps ≤ 0.008) and subsequently increased at postpartum (p < 0.001). Black women exhibited significantly higher serum BDNF during the 1st trimester, 2nd trimester, and postpartum (ps ≤ 0.032) as well as lower serum cortisol during the 2nd and 3rd trimester (ps ≤ 0.01). Higher serum cortisol was concurrently associated with lower serum BDNF in the 2nd trimester only (p < 0.05). Controlling for race, serum BDNF at both the 2nd and 3rd trimester was negatively associated with 3rd trimester depressive symptoms (ps ≤ 0.02). In addition, women delivering low versus healthy weight infants showed significantly lower serum BDNF in the 3rd trimester (p = 0.004). Women delivering low versus healthy weight infants did not differ in depressive symptoms at any time point during pregnancy (ps ≥ 0.34). Serum BDNF declines considerably across pregnancy in Black and White women, with overall higher levels in Blacks. Lower serum BDNF in late pregnancy corresponds with higher depressive symptoms and risk for low birth weight in Black and White women. However, the predictive value of serum BDNF in pregnancy is specific to within-race comparisons. Potential links between racial differences in serum BDNF and differential pregnancy-related cortisol adaptation require further investigation.
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